04-886
Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W, rabbit monoclonal
culture supernatant, clone A11W, from rabbit
Synonym(e):
signal transducer and activator of transcription 5A, signal transducer and activator of transcription 5B, transcription factor STAT5B
Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(2)
About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
rabbit
Qualitätsniveau
Antikörperform
culture supernatant
Antikörper-Produkttyp
primary antibodies
Klon
A11W, monoclonal
Speziesreaktivität
rat, chimpanzee, human, mouse, bovine
Methode(n)
western blot: suitable
Isotyp
IgG
Eignung
not suitable for immunoprecipitation
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Posttranslationale Modifikation Target
phosphorylation (pTyr694/pTyr699)
Angaben zum Gen
bovine ... Stat5A(282375)
Allgemeine Beschreibung
The STAT proteins (signal transducer and activator of transcription) comprise a family of transcription factors. STATs are activated through tyrosine phosphorylation, mainly by JAK kinases, which results in their dimerization, nuclear translocation and regulation of gene expression. STAT5 activity is induced by numerous cytokines and growth factors. While STAT5A and STAT5B share 96% amino acid homology, the two isoforms have distinct physiological functions. Phosphorylation of tyrosine 694/699 is a key marker of STAT5A/B activation.
Spezifität
Phospho-STAT5A/B (Tyr694/699).
Immunogen
Epitope: pTyr694/699
KLH-conjugated, synthetic peptide containing the sequence DGpYVK in which pY corresponds to phospho-tyrosine at residue 694 of human STAT5A or residue 699 of STAT5B.
Anwendung
Research Category
Zelluläre Signaltransduktion
Apoptose & Krebs
Zelluläre Signaltransduktion
Apoptose & Krebs
Research Sub Category
Transkriptionsfaktoren
Transkriptionsfaktoren
Detect phospho-STAT5A/B (Tyr694/699) using this Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W validated for use in WB.
Qualität
Evaluated by western blot on RIPA lysates from 3T3/NIH cells untreated and treated with PDGF.
Western Blot Analysis:
A 1:1,000-1:2,000 dilution of this antibody detected phospho-STAT5A/B (Tyr694/699) in lysates from 3T3/NIH cells treated with PDGF.
Western Blot Analysis:
A 1:1,000-1:2,000 dilution of this antibody detected phospho-STAT5A/B (Tyr694/699) in lysates from 3T3/NIH cells treated with PDGF.
Zielbeschreibung
~95 kDa
Verlinkung
Replaces: 05-886
Physikalische Form
Cultured supernatant containing 0.05% sodium azide.
Lagerung und Haltbarkeit
Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Hinweis zur Analyse
Control
PDGF treated 3T3/NIH cells
PDGF treated 3T3/NIH cells
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
12 - Non Combustible Liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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B Sporri et al.
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