04-001
Anti-JAK2 Antibody, clone 8E10.2
clone 8E10.2, Upstate®, from mouse
Synonym(e):
Janus kinase 2, Tyrosine kinase
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Alle Fotos(5)
About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.43
Empfohlene Produkte
Biologische Quelle
mouse
Qualitätsniveau
Antikörperform
purified antibody
Antikörper-Produkttyp
primary antibodies
Klon
8E10.2, monoclonal
Speziesreaktivität
mouse, human, rat
Verpackung
antibody small pack of 25 μg
Hersteller/Markenname
Upstate®
Methode(n)
immunohistochemistry: suitable (paraffin)
western blot: suitable
Isotyp
IgG1κ
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
ambient
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... JAK2(3717)
mouse ... Jak2(16452)
rat ... Jak2(24514)
Allgemeine Beschreibung
JAK2 (Janus Kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerizes and translocates to the nucleus and bind to CIS elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
Spezifität
This antibody recognizes Jak2.
Immunogen
KLH-conjugated linear peptide.
Anwendung
Research Category
Entzündung & Immunologie
Entzündung & Immunologie
Research Sub Category
Immunologische Signalübertragung
Immunologische Signalübertragung
Western Blot Analysis: 0.5-1 μg/mL of this lot was used to detect Jak2 in L6 cell lysates.
Immunohistochemistry(Paraffin):
A previous lot of this antibody was used in immunohistochemistry(paraffin) staining with eptiope retrieval: Human Cancer Array.
Immunohistochemistry(Paraffin):
A previous lot of this antibody was used in immunohistochemistry(paraffin) staining with eptiope retrieval: Human Cancer Array.
Anti-JAK2 Antibody, clone 8E10.2 detects level of JAK2 & has been published & validated for use in WB, IH(P).
Qualität
Routinely evaluated by western blot on L6 cell lysate.
Zielbeschreibung
130 kDa
Physikalische Form
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH7.4), 150 mM NaCl with 0.05% sodium azide
Lagerung und Haltbarkeit
Stable for 1 year at 2-8°C from date of receipt.
Hinweis zur Analyse
Control
L6 cell lysate
L6 cell lysate
Sonstige Hinweise
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Rechtliche Hinweise
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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