S-026

(±)-Sertraline-D₃ hydrochloride solution

100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Synonym(e): (±)-Sertraline-D₃ Hydrochloride Standard Solution
• Empirische Formel (Hill-System): C₁₇D₃H₁₄Cl₂N · HCl
• Molekulargewicht: 345.71
• MDL-Nummer: MFCD09955572
• UNSPSC-Code: 41116107
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material
• Form: liquid
• Leistungsmerkmale: Snap-N-Spike^®/Snap-N-Shoot^®
• Verpackung: ampule of 1 mL
• Hersteller/Markenname: Cerilliant^®
• Konzentration: 100 μg/mL in methanol (as free base)
• Methode(n): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Anwendung(en): clinical testing
• Format: single component solution
• Lagertemp.: −20°C
• SMILES String: ClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC([2H])([2H])[2H])CC2)=C1.[H]Cl
• InChI: 1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1/i1D3;
• InChIKey: BLFQGGGGFNSJKA-FEGLBNOFSA-N

Beschreibung

Allgemeine Beschreibung

Sertraline, marketed as the brand drug Zoloft^®, is an SSRI antidepressant used in the treatment of major depression as well as obsessive-compulsive, panic, and social anxiety disorders. This new internal standard is suitable for the quantitation of sertraline in biological samples using LC/MS or GC/MS applications.

Anwendung

• Sertraline-D₃ as a research tool in environmental studies: Sertraline-D₃ hydrochloride solution is utilized in environmental research to detect and analyze the presence of pharmaceutical compounds in wildlife, such as in the study of neonicotinoids and pharmaceuticals found in the hair of red foxes, providing insights into environmental exposure and accumulation (Picone et al., 2023).


• Pharmaceutical wastewater analysis: This solution is critical in assessing the efficacy of wastewater treatment processes in removing pharmaceutical active compounds, highlighting its role in environmental safety and public health (Kosma et al., 2020).


• Advancements in chromatography: Sertraline-D₃ hydrochloride is used in liquid chromatography-tandem mass spectrometry for the rapid quantitative analysis of pharmaceuticals, demonstrating its essential role in developing precise analytical techniques (Sharma et al., 2015).


• Quantitative drug analysis in biomedicine: The compound serves as a standard in high-performance liquid chromatography studies to quantify multiple antidepressants in biological samples, aiding in therapeutic drug monitoring and pharmacokinetic studies (Amundsen et al., 2013).


• Therapeutic drug monitoring: Employed in the simultaneous quantification of selective serotonin reuptake inhibitors and their metabolites, Sertraline-D₃ hydrochloride enhances the reliability of measurements in clinical pharmacology, supporting its use in medical diagnostics and treatment efficacy assessments (Ansermot et al., 2012).

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Zoloft is a registered trademark of Pfizer, Inc.

Sicherheitshinweise

• Piktogramme: GHS02,GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H225,H301 + H311 + H331,H370
• P-Sätze: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Zielorgane: Eyes
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 1
• Flammpunkt (°F): 49.5 °F - closed cup
• Flammpunkt (°C): 9.7 °C - closed cup