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890705P

Avanti

16:0-18:1 EPC (Cl Salt)

Avanti Research - A Croda Brand 890705P, powder

Synonym(e):

1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

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10 MG
151,00 €
25 MG
195,00 €

151,00 €


Versandbereit am07. April 2025Details


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10 MG
151,00 €
25 MG
195,00 €

About This Item

Empirische Formel (Hill-System):
C44H87NO8PCl
CAS-Nummer:
Molekulargewicht:
824.59
MDL-Nummer:
UNSPSC-Code:
12352211
NACRES:
NA.25

151,00 €


Versandbereit am07. April 2025Details


Bulk-Bestellung anfordern

Form

powder

Verpackung

pkg of 1 × 10 mg (890705P-10mg)
pkg of 1 × 25 mg (890705P-25mg)

Hersteller/Markenname

Avanti Research - A Croda Brand 890705P

Anwendung(en)

advanced drug delivery

Lipid-Typ

transfection
cationic lipids

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)OCC.[Cl-]

InChI

1S/C44H87NO8P.ClH/c1-7-10-12-14-16-18-20-22-23-25-27-29-31-33-35-37-44(47)53-42(41-52-54(48,50-9-3)51-39-38-45(4,5)6)40-49-43(46)36-34-32-30-28-26-24-21-19-17-15-13-11-8-2;/h22-23,42H,7-21,24-41H2,1-6H3;1H/q+1;/p-1/b23-22-;/t42-,54?;/m1./s1

InChIKey

SXRDCCSKGWBZFF-ISBKSCLYSA-M

Allgemeine Beschreibung

1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (16:0-18:1 EPC) is cationic lipid containing an ethyl group attached to the phosphate moiety through an ester bond and has a choline headgroup.[1]

Anwendung

1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (chloride salt) (16:0-18:1 EPC (Cl Salt)) might be used:
  • as a cationic lipid to explore the change in organization and dynamics of a membrane-bound fluorescent probe in host membranes of varying charge[1]
  • in the preparation of small unilamellar cationic liposomes [2]
  • in a novel albumin-associated lipoplex formulation to evaluate the antitumoral efficacy of immuno-gene therapy and “suicide” gene therapy[3]

Biochem./physiol. Wirkung

1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (16:0-18:1 EPC) is a potential transfection agent, which is also similar to the natural lipids.[1]

Verpackung

5 mL Clear Glass Sealed Ampule (890705P-10mg)
5 mL Clear Glass Sealed Ampule (890705P-25mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids


Hier finden Sie alle aktuellen Versionen:

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Modulation of fluorophore environment in host membranes of varying charge
Kelkar DA, et al.
Journal of Fluorescence, 13(6), 459-466 (2003)
Marta Passadouro et al.
International journal of nanomedicine, 9, 3203-3217 (2014-07-26)
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and mortal cancer, characterized by a set of known mutations, invasive features, and aberrant microRNA expression that have been associated with hallmark malignant properties of PDAC. The lack of effective PDAC treatment
H Faneca et al.
Biochimica et biophysica acta, 1768(5), 1093-1102 (2007-02-14)
In the present work, we used a novel albumin-associated lipoplex formulation, containing the cationic lipid 1-palmitoyl-2-oleoyl-sn-glycero-3-ethylphosphocholine (EPOPC) and cholesterol (Chol), to evaluate the antitumoral efficacy of two gene therapy strategies: immuno-gene therapy, mediated by IL-12 gene expression, and "suicide" gene
Wei Zong et al.
Langmuir : the ACS journal of surfaces and colloids, 34(23), 6874-6886 (2018-05-20)
The success of nanoparticulate formulations in drug delivery depends on various aspects including their toxicity, internalization, and intracellular location. Vesicular assemblies consisting of phospholipids and amphiphilic block copolymers are an emerging platform, which combines the benefits from liposomes and polymersomes
Li Wang et al.
Molecular pharmaceutics, 4(4), 615-623 (2007-04-06)
To date, the primary approach to improving the transfection properties of cationic lipids has been the synthesis of new kinds of cationic amphipaths. Recently, however, it was found that combining two cationic lipid derivatives having the same head group but

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