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P51559

Sigma-Aldrich

Propionylchlorid

98%

Synonym(e):

Chloro ethyl ketone, Ethyl chloroform, Propionic acid chloride, Prorionyl chloride

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43,20 €
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25 G
43,20 €
500 G
69,20 €

About This Item

Lineare Formel:
CH3CH2COCl
CAS-Nummer:
79-03-8
Molekulargewicht:
92.52
Beilstein:
385632
EG-Nummer:
201-170-0
MDL-Nummer:
MFCD00000745
UNSPSC-Code:
12352100
PubChem Substanz-ID:
24898602
NACRES:
NA.22

43,20 €

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Dampfdichte

3.2 (vs air)

Qualitätsniveau

200

Assay

98%

Brechungsindex

n20/D 1.404 (lit.)

bp

77-79 °C (lit.)

mp (Schmelzpunkt)

−94 °C

Dichte

1.059 g/mL at 25 °C (lit.)

SMILES String

CCC(Cl)=O

InChI

1S/C3H5ClO/c1-2-3(4)5/h2H2,1H3

InChIKey

RZWZRACFZGVKFM-UHFFFAOYSA-N

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Allgemeine Beschreibung

Propionyl chloride is an important chemical intermediate used to synthesize various propionic acid derivatives.

Anwendung

Propionyl chloride can be used as an acylating agent:
  • To convert anisole to 4-methoxypropiophenone and 2-methoxynaphthalene to 1-propio-2-methoxynaphthalene in the presence of Indium(III) chloride (InCl3) impregnated mesoporous Si-MCM-41 catalyst.[1]

It can also be used:
  • For chlorination in the presence of sulfuryl chloride and peroxides to form α-chloropropionyl chloride and β-chloropropionyl chloride.[2]
  • In reaction with (hydroxypropyl)cellulose to form the propanoate ester, [(propionyloxy)propyl]cellulose.[3]

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

Zusätzliche Gefahrenhinweise

EUH014

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 1

Flammpunkt (°F)

42.8 °F - closed cup

Flammpunkt (°C)

6 °C - closed cup

Persönliche Schutzausrüstung

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000178015
0000185870
STBK0071
STBJ4745
STBJ2165

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Chlorinations with Sulfuryl Chloride. III.(a) The Peroxide-Catalyzed Chlorination of Aliphatic Acids and Acid Chlorides.(b) The Photochemical Sulfonation of Aliphatic Acids
Kharasch MS and Brown HC
Journal of the American Chemical Society, 62(4), 925-929 (1940)
The propanoate ester of (2-hydroxypropyl) cellulose: a thermotropic cholesteric polymer that reflects visible light at ambient temperatures
Tseng SL, et L.
Macromolecules, 15(5), 1262-1264 (1982)
Yu Duan et al.
Molecular medicine reports, 16(6), 9735-9740 (2017-10-19)
The aim of the present study was to report on a complete synthetic approach, namely benzylation-hydrolysis-acylation‑hydrogenation, to the synthesis of regioselectively acylated quercetin analogues using low‑cost rutin as a starting material. Three quercetin analogues, quercetin‑3‑O‑propionate (Q‑pr), quercetin‑3‑O‑butyrate (Q‑bu) and quercetin‑3‑O‑valerate
Douglas T Durig et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 60(7), 1481-1504 (2004-05-19)
Variable temperature (-60 to -100 degrees C) studies of the infrared spectra (3500-400 cm(-1)) of propionyl fluoride (CH3CH2CFO) and 2-methylpropionyl fluoride ((CH3)2CHCFO), dissolved in liquid xenon have been recorded. From these data, the enthalpy difference has been determined to be
Joanna Kurczewska et al.
International journal of pharmaceutics, 486(1-2), 226-231 (2015-04-07)
Vancomycin was immobilized on three different organically functionalized silicas. The materials obtained were used for a controlled release of the antibiotic. The influence of the type of chemical bond on the in vitro drug release was investigated. A weak ionic
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Fragen

1-3 von 3 Fragen  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 Antwort

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 Antwort

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. How to do assy by titration with naoh solution

    1 Antwort

    1. This product is tested by silver nitrate titration. The method is considered proprietary, the link below describes the general principle and offers a basic protocol:
      https://www.canterbury.ac.nz/media/documents/science-outreach/chloride_volhard.pdf
      Please refer to the literature for sodium hydroxide methods. The reference below may be helpful.
      https://www.sciencedirect.com/science/article/abs/pii/B9780124115187000056

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