923273

2-((3aR,7aR)-1-(tert-Butoxycarbonyl)octahydro-6H-pyrrolo[2,3-c]pyridin-6-yl)thiazole-4-carboxylic acid

• Synonym(e): Rigid linker for PROTAC^® development
• Empirische Formel (Hill-System): C₁₆H₂₃N₃O₄S
• Molekulargewicht: 353.44
• UNSPSC-Code: 12352106
• NACRES: NA.22

Eigenschaften

• Form: powder
• Qualitätsniveau: 100
• Eignung der Reaktion: reagent type: linker
• Funktionelle Gruppe: Boc; carboxylic acid
• Lagertemp.: 2-8°C
• SMILES String: [H][C@]12[C@](N(C(OC(C)(C)C)=O)CC2)([H])CN(C3=NC(C(O)=O)=CS3)CC1

Beschreibung

Anwendung

2-((3aR,7aR)-1-(tert-Butoxycarbonyl)octahydro-6H-pyrrolo[2,3-c]pyridin-6-yl)thiazole-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:

923281

923303

Sonstige Hinweise

Protein Degrader Building Blocks


Crosslinkers for Bioconjugation


Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable