539112

4-Brom-1-fluor-2-nitrobenzol

96%

• Lineare Formel: BrC₆H₃(F)NO₂
• CAS-Nummer: 364-73-8
• Molekulargewicht: 220.00
• MDL-Nummer: MFCD00129165
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24878380
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 96%
• Brechungsindex: n20/D 1.575 (lit.)
• bp: 240-241 °C (lit.)
• mp (Schmelzpunkt): 18-19 °C (lit.)
• Dichte: 1.786 g/mL at 25 °C (lit.)
• Funktionelle Gruppe: bromo; fluoro; nitro
• SMILES String: [O-][N+](=O)c1cc(Br)ccc1F
• InChI: 1S/C6H3BrFNO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H
• InChIKey: UQEANKGXXSENNF-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

4-Bromo-1-fluoro-2-nitrobenzene undergoes Sonogashira reaction with 2-fluoronitrobenzene to afford predominantly the bromo displacement product.[1]

Anwendung

Used in the synthesis of anti-inflammatory agents.[2]

4-Bromo-1-fluoro-2-nitrobenzene may be used in the synthesis of:

• 6-bromo-1H-benzo[d][1,2,3]triazol-1-ol[3]
• 2-(4-bromo-2-nitrophenylamino)-5-methylthiophene-3-carbonitrile[4]
• dibenzoxazepine analog, as potent sodium channel blocker[5]
• 4-(4-bromo-2-nitrophenyl)piperazine-1-carboxylic acid tert-butylester[6]

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves