47672

Fmoc-Asn(Trt)-OH

≥97.0%, for peptide synthesis

• Synonym(e): N_α-(9-Fluorenylmethoxycarbonyl)-N_γ-trityl-L-asparagin, N_α-Fmoc-N_γ-trityl-L-asparagin
• Empirische Formel (Hill-System): C₃₈H₃₂N₂O₅
• CAS-Nummer: 132388-59-1
• Molekulargewicht: 596.67
• Beilstein: 4343823
• MDL-Nummer: MFCD00077049
• UNSPSC-Code: 12352209
• eCl@ss: 32160406
• PubChem Substanz-ID: 57651076
• NACRES: NA.26

Eigenschaften

• product name: Fmoc-Asn(Trt)-OH, ≥97.0%
• Assay: ≥97.0%
• Form: powder
• Optische Aktivität: [α]20/D −15.0±1°, c = 1% in methanol
• Eignung der Reaktion: reaction type: Fmoc solid-phase peptide synthesis
• mp (Schmelzpunkt): 201-204 °C (lit.)
• Anwendung(en): peptide synthesis
• Funktionelle Gruppe: Fmoc
• Lagertemp.: 2-8°C
• SMILES String: OC(=O)[C@H](CC(=O)NC(c1ccccc1)(c2ccccc2)c3ccccc3)NC(=O)OCC4c5ccccc5-c6ccccc46
• InChI: 1S/C38H32N2O5/c41-35(40-38(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28)24-34(36(42)43)39-37(44)45-25-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33/h1-23,33-34H,24-25H2,(H,39,44)(H,40,41)(H,42,43)/t34-/m0/s1
• InChIKey: KJYAFJQCGPUXJY-UMSFTDKQSA-N

Beschreibung

Allgemeine Beschreibung

Fmoc-Asn(Trt)-OH has good solubility properties in most organic solvents, and its use has been shown to result in significantly purer peptides than other derivatives used for the introduction of Asn [1, 2]. Coupling can be performed by standard procedures. The trityl group is normally removed by 95% TFA in 1-3 hours, with no alkylation of Trp residues. When Asn(Trt) is the N-terminal residue, the reaction time may need to be extended to ensure complete deprotection [3].

Anwendung

Fmoc-Asn(Trt)-OH has been used to synthesize peptides on cellulose membrane by SPOT method

Sicherheitshinweise

• Piktogramme: GHS09
• H-Sätze: H411
• Gefahreneinstufungen: Aquatic Chronic 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)