41996

1-Hydroxy-7-azabenzotriazol -Lösung

~0.6 M in DMF, for peptide synthesis

• Synonym(e): 3H-[1,2,3]-Triazolo[4,5-b]pyridin-3-ol, HOAt
• Empirische Formel (Hill-System): C₅H₄N₄O
• CAS-Nummer: 39968-33-7
• Molekulargewicht: 136.11
• Beilstein: 1211115
• MDL-Nummer: MFCD00210053
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 57650093
• NACRES: NA.22

Eigenschaften

• product name: 1-Hydroxy-7-azabenzotriazol -Lösung, ~0.6 M in DMF
• Form: liquid
• Eignung der Reaktion: reaction type: Addition Reactions
• Konzentration: ~0.6 M in DMF
• Verunreinigungen: <1.0% water
• Brechungsindex: n20/D 1.441
• Dichte: 0.978 g/mL at 20 °C
• Anwendung(en): peptide synthesis
• SMILES String: On1nnc2cccnc12
• InChI: 1S/C5H4N4O/c10-9-5-4(7-8-9)2-1-3-6-5/h1-3,10H
• InChIKey: FPIRBHDGWMWJEP-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

1-Hydroxy-7-azabenzotriazole solution, also known as 3H-[1,2,3]-triazolo[4,5-b]pyridin-3-ol, is a benzotriazolic additive that is commonly used as a coupling reagent for amino acids and peptides. It is also used to minimize epimerization.

Anwendung

1-Hydroxy-7-azabenzotriazole solution is used as a reagent in the solid-phase synthesis of chiral peptide nucleic acids.

Sonstige Hinweise

Coupling additive for efficient racemization-free coupling in peptide synthesis; segment coupling.

Sicherheitshinweise

• Piktogramme: GHS02,GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H226,H312 + H332,H319,H360D
• P-Sätze: P210 - P280 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): 136.4 °F - closed cup
• Flammpunkt (°C): 58 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter