343935

4-Chlorbutyrylchlorid

technical grade, 95%

• Lineare Formel: Cl(CH₂)₃COCl
• CAS-Nummer: 4635-59-0
• Molekulargewicht: 141.00
• Beilstein: 773860
• EG-Nummer: 225-059-1
• MDL-Nummer: MFCD00000754
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24861217
• NACRES: NA.22

Eigenschaften

• Qualität: technical grade
• Dampfdruck: 3 mmHg ( 20 °C)
• Assay: 95%
• Form: liquid
• Selbstzündungstemp.: 824 °F
• Brechungsindex: n20/D 1.461 (lit.)
• bp: 173-174 °C (lit.)
• Dichte: 1.26 g/mL at 25 °C (lit.)
• Funktionelle Gruppe: acyl chloride; chloro
• SMILES String: ClCCCC(Cl)=O
• InChI: 1S/C4H6Cl2O/c5-3-1-2-4(6)7/h1-3H2
• InChIKey: CDIIZULDSLKBKV-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

4-Chlorobutyryl chloride is a chloroacyl chloride. It undergoes coupling with 4-carboxyphenylboronic acid under standard Suzuki coupling conditions [Pd(PPh₃)₄, Na₂CO₃, DME/H₂O] to give 2′-methyl-4′-(2-oxo-1-pyrrolidinyl)biphenyl-4-carboxylic acid. Synthesis of 4-chlorobutyryl chloride using γ-butyroctone has been reported.3

Anwendung

4-Chlorobutyryl chloride may be used in the radiosynthesis of (11)C-levetiracetam, a potential marker for PET imaging of SV2A expression. It may be used in the preparation of N-chloroacyl-6-O-triphenylmethylchitosans.

Sicherheitshinweise

• Piktogramme: GHS06,GHS05,GHS09
• Signalwort: Danger
• H-Sätze: H290,H302,H314,H330,H400
• P-Sätze: P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1A
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 1
• Flammpunkt (°F): 185.0 °F
• Flammpunkt (°C): 85 °C
• Persönliche Schutzausrüstung: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter