1268750

Etomidate

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): (R)-1-(α-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester, Amidate, R16659
• Empirical Formula (Hill Notation): C₁₄H₁₆N₂O₂
• CAS Number: 33125-97-2
• Molecular Weight: 244.29
• NACRES: NA.24
• PubChem Substance ID: 329749815
• UNSPSC Code: 41116107
• MDL number: MFCD00869295

Properties

• grade: pharmaceutical primary standard
• agency: USP
• API family: etomidate
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: CCOC(=O)c1cncn1[C@H](C)c2ccccc2
• InChI: 1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
• InChI key: NPUKDXXFDDZOKR-LLVKDONJSA-N
• Gene Information: human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Etomidate is a general anesthetic; potentiates GABA_A transmission

Etomidate is a general anesthetic; potentiates GABAA transmission. The possible neuroprotective effect of etomidate against streptozotocin-induced (STZ-induced) hyperglycaemia were investigated in the rat brain and spinal cord. Etomidate treatment demonstrated neuroprotective effect on the neuronal tissue against the diabetic oxidative damage

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302,H410
• pcodes: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable