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T8200

Tofisopam

≥98% (HPLC), solid

Synonym(s):

7,8-Dimethoxy-1-(3,4-dimethoxyphenyl)-5-ethyl-4-methyl-5H-2,3-benzodiazepine, EGYT 341, Seriel

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Pack SizeSKUAvailabilityPrice
10 mg
Please contact Customer Service for Availability
CZK 6,070.00
50 mg
Please contact Customer Service for Availability
CZK 13,900.00
CZK 11,815.00

About This Item

Empirical Formula (Hill Notation):
C22H26N2O4
CAS Number:
22345-47-7
Molecular Weight:
382.45
NACRES:
NA.77
PubChem Substance ID:
24724636
UNSPSC Code:
12352200
EC Number:
244-922-3
MDL number:
MFCD00823171
Assay:
≥98% (HPLC)
Form:
solid

CZK 6,070.00

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Quality Segment

100

assay

≥98% (HPLC)

form

solid

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

white

solubility

DMSO: ~14 mg/mL, H2O: insoluble

SMILES string

CCC1C(C)=NN=C(c2ccc(OC)c(OC)c2)c3cc(OC)c(OC)cc13

InChI

1S/C22H26N2O4/c1-7-15-13(2)23-24-22(14-8-9-18(25-3)19(10-14)26-4)17-12-21(28-6)20(27-5)11-16(15)17/h8-12,15H,7H2,1-6H3

InChI key

RUJBDQSFYCKFAA-UHFFFAOYSA-N

Application

Tofisopam has been used for studying its biochemical mechanisms of actions using drug repositioning strategies[1].

Biochem/physiol Actions

Ligand for the GABAA receptor benzodiazepine modulatory site.
Studies have reported that tofisopam functions by blocking PDE4 (phosphodiesterase 4). Furthermore, the S-enantiomer of tofisopam is considered ten times more active than R-enantiomer[1].

Preparation Note

Tofisopam is soluble in DMSO at approximately 14 mg/ml. However, it is insoluble in water.

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This Item
G1421SML0686UC175
Tofisopam ≥98% (HPLC), solid

Sigma-Aldrich

T8200

Tofisopam

GW405833 hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

G1421

GW405833 hydrochloride

Talampanel ≥97% (HPLC)

Sigma-Aldrich

SML0686

Talampanel

(S)-(+)-Mephenytoin solid, ≥98% (HPLC)

Sigma-Aldrich

UC175

(S)-(+)-Mephenytoin

form

solid

form

solid

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

drug control

-

drug control

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

solubility

DMSO: ~14 mg/mL, H2O: insoluble

solubility

DMSO: soluble >10 mg/mL, H2O: insoluble <2 mg/mL

solubility

DMSO: 15 mg/mL, clear

solubility

DMSO: soluble

color

white

color

white to pink

color

white to beige

color

off-white

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H400

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000414970
0000414970
0000105557
0000105555
0000103849

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Global Trade Item Number

SKUGTIN
T8200-50MG04061832561318
T8200-10MG04061832561301

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