T5639

Ticarcillin disodium salt

• Synonym(s): (2S,5R,6R)-6-[[(2R)-Carboxy-3-thienylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt
• Empirical Formula (Hill Notation): C₁₅H₁₄N₂Na₂O₆S₂
• CAS Number: 4697-14-7
• Molecular Weight: 428.39
• NACRES: NA.85
• PubChem Substance ID: 24900306
• UNSPSC Code: 51282427
• MDL number: MFCD07787410

Properties

• biological source: semisynthetic
• Quality Segment: 200
• form: powder or crystals
• color: white to light yellow
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria
• mode of action: cell wall synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](C([O-])=O)c3ccsc3)C(=O)N2[C@H]1C([O-])=O
• InChI: 1S/C15H16N2O6S2.2Na/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6;;/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23);;/q;2*+1/p-2/t7-,8-,9+,12-;;/m1../s1
• InChI key: ZBBCUBMBMZNEME-QBGWIPKPSA-L

Description

General description

Chemical structure: β-lactam

Application

Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. It is commonly used in combination with clavulanate in order to improve it′s efficacy[1]. It is used to study appropriate dosing in pediatric patients who have cystic fibrosis[2].

Biochem/physiol Actions

Ticarcillin is a β-Lactam antibiotic that prevents bacterial cell wall biosynthesis at the level of peptidogylcan cross-linking by inhibiting peptidoglycan transpeptidases. It is derived from penicillin and is similar to carbenicillin in action. Ticarcillin is susceptible to degradation by β-lactamases[1].

Packaging

1G

Preparation Note

Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.

Other Notes

β-Lactam antibiotic

Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.

Safety Information

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H315,H319,H334,H335
• pcodes: P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves