T5080

Thymulin

lyophilized powder

• Synonym(s): Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH trifluoroacetate salt, STF, Serum Thymic Factor
• Empirical Formula (Hill Notation): C₃₃H₅₄N₁₂O₁₅
• CAS Number: 63958-90-7
• Molecular Weight: 858.85
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826807
• MDL number: MFCD00076882

Properties

• biological source: synthetic (organic)
• assay: 97-100% (HPLC)
• form: lyophilized powder
• color: white
• solubility: deionized water: soluble
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: C[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(O)=O
• InChI: 1S/C33H54N12O15/c1-15(39-29(55)18-6-8-24(50)40-18)27(53)42-16(4-2-3-9-34)30(56)45-21(14-47)32(58)43-17(5-7-22(35)48)28(54)38-11-25(51)37-12-26(52)41-20(13-46)31(57)44-19(33(59)60)10-23(36)49/h15-21,46-47H,2-14,34H2,1H3,(H2,35,48)(H2,36,49)(H,37,51)(H,38,54)(H,39,55)(H,40,50)(H,41,52)(H,42,53)(H,43,58)(H,44,57)(H,45,56)(H,59,60)/t15-,16-,17-,18-,19-,20-,21-/m0/s1
• InChI key: LIFNDDBLJFPEAN-BPSSIEEOSA-N

Description

Application

Thymulin was used to study the impact of this compound on gonadotrophin-induced ovulation and on onset of puberty in mice.[1]

Biochem/physiol Actions

Thymulin also refers as serum thymic factor is a nonapeptide that reduces the hyperalgesia induced due to peripheral endotoxin administration in rats and mice.[2] It also possesses an immunomodulator function by regulating the cytokine production by peripheral blood mononuclear cells (PBMC).[3]

Thymulin, also known as Thymic Factor, is a nonapeptide produced by epithelial cell popuation in the thymus. This peptide is known for its immunomodulatory role and has neuroendocrine effects as well.

Physical form

Lyophilized from 0.1% aqueous TFA.

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable