T3694
Tetanus toxin C fragment
from Clostridium tetani, neurotoxin
Synonym(s):
TTC
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| Size/SKU | Availability | Price |
|---|---|---|
10 μg | Please contact Customer Service for Availability | CZK 21,100.00 CZK 17,935.00 |
About This Item
CZK 17,935.00
List PriceCZK 21,100.00Save 15%Please contact Customer Service for Availability
Product Name
Tetanus toxin C fragment from Clostridium tetani,
mol wt
apparent mol wt 47 kDa
Quality Segment
color
white
solubility
H2O: soluble
storage temp.
2-8°C
General description
Tetanus toxin C fragment (TTC) is a non-toxic peptide, which is transported from peripheral axons into spinal motoneurons. It provides protection for motoneurons (MN) in the spinal cord in vivo. TTC regulates membrane binding, internalization and retrograde transport within MN. It initiates neurotrophin-regulated signaling pathways in a Trk receptor-dependent manner. TTC has neuroprotective property in primary cerebellar granule cell culture.
Application
The C terminal binding portion of tetanus toxin is not toxic but is taken up by pre-synaptic nerve terminals and exhibits trans-synaptic retrograde transport in central neurons similar to that of tetanus toxin.
The C terminal binding portion of tetanus toxin is not toxic but is taken up by pre-synaptic nerve terminals and exhibits trans-synaptic retrograde transport in central neurons similar to that of tetanus toxin. It is used to map neuronal connections and to target proteins to neurons.
Biochem/physiol Actions
Tetanus toxin is a neurotoxin that comprises of a heavy and a light chain linked by disulfide bridges. This neurotoxin enters the cytoplasm and releases the light chain component that subsequently inhibits the release of neurotransmitters2. Studies have reported that the fragment C of tetanus toxin retains most of the determinants that interact with thyroid membranes, gangliosides and neural membranes3.
Preparation Note
Each vial, when reconstituted with 50 μl of sterile distilled water, contains 10 μg of tetanus toxin C-fragment in 0.01 M sodium phosphate, pH 7.5. To aid recovery, 0.1% albumin may be added.
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This Item | |||
|---|---|---|---|
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 200 |
| mol wt apparent mol wt 47 kDa | mol wt - | mol wt 150 kDa (heavy chain (100 kDa) and a light chain (50 kDa) connected through an interchain disulfide bond) | mol wt - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility H2O: soluble | solubility sterile distilled water: soluble | solubility H2O: soluble | solubility soluble (Reconstitute in 50 µl of sterile distilled H2O) |
| color white | color - | color - | color - |
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - STOT SE 1
target_organs
Central nervous system
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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