T3577

Tolperisone hydrochloride

≥98% (HPLC), ion channel blocker , solid

• Synonym(s): Menopatol, 2-Methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one hydrochloride
• Empirical Formula (Hill Notation): C₁₆H₂₃NO · HCl
• CAS Number: 3644-61-9
• Molecular Weight: 281.82
• NACRES: NA.77
• PubChem Substance ID: 329826771
• UNSPSC Code: 12352200
• EC Number: 222-876-5
• MDL number: MFCD00058211
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Properties

• Product Name: Tolperisone hydrochloride, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white
• solubility: H₂O: >20 mg/mL
• storage temp.: room temp
• SMILES string: Cl.CC(CN1CCCCC1)C(=O)c2ccc(C)cc2
• InChI: 1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H
• InChI key: ZBUVYROEHQQAKL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Tolperisone is an ion channel blocker and centrally acting muscle relaxant.

Tolperisone regulates ionic currents in myelinates axons and subsequently decreases excitability and mediates its antispastic functions³.

Tolperisone is derived from piperidine and possesses membrane stabilizing action. It helps in reducing the effect of spasticities associated with the nervous and muscular system. It exhibits muscle relaxant action through attenuating voltage-gated sodium channels in the brain stem.

Preparation Note

Tolperisone hydrochloride dissolves in water at a concentration that is greater than 20 mg/ml.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332
• pcodes: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves