T3439

Tumor Necrosis Factor Soluble Receptor I (TNF sRI)/Fc Chimera human

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

• UNSPSC Code: 51111800
• NACRES: NA.32
• MDL number: MFCD02689207
• Form: lyophilized powder
• Assay: ≥95% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in NSO cells
• Mol wt: 48 kDa

Properties

• biological source: human
• Quality Segment: 100
• recombinant: expressed in NSO cells
• assay: ≥95% (SDS-PAGE)
• form: lyophilized powder
• potency: 0.4-2 ng/mL ED₅₀
• mol wt: 48 kDa
• packaging: pkg of 50 μg
• storage condition: avoid repeated freeze/thaw cycles
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• UniProt accession no.: P20333
• storage temp.: −20°C
• Gene Information: human ... TNFRSF1B(7133)

Description

Application

Tumor Necrosis Factor Soluble Receptor I (TNF sRI)/Fc Chimera human may be used to study signaling of apoptosis and NF-κB activation.

Biochem/physiol Actions

Tumor Necrosis Factor Soluble Receptor I (TNF sRI)/Fc Chimera human belongs to TNF family of receptors and has a pivotal role in neutralizing the biological activities of both TNF-α and TNF-β. Soluble tumor necrosis factor receptor along with intrathecal interleukin-1 receptor antagonist shows an anti-allodynic action in rat L5 spinal nerve transection model of neuropathic pain.[1]

Physical form

Lyophilized from 0.2 um-filtered solution in PBS, pH 7.4 with 50 µg BSA.

Analysis Note

The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 0.25 ng/ml recombinant human TNF-α.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable