T0202

Tocainide hydrochloride

≥98% (HPLC), sodium channel blocker, solid

• Synonym(s): 2-Amino-N-(2,6-dimethylphenyl)propanamide hydrochloride
• Empirical Formula (Hill Notation): C₁₁H₁₆N₂O · HCl
• CAS Number: 71395-14-7
• Molecular Weight: 228.72
• NACRES: NA.77
• PubChem Substance ID: 24724626
• UNSPSC Code: 12352200
• EC Number: 275-361-2
• MDL number: MFCD00941502
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated, under inert gas

Properties

• Product Name: Tocainide hydrochloride, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated, under inert gas
• color: white
• solubility: DMSO: >20 mg/mL, H₂O: ≥5 mg/mL
• originator: AstraZeneca
• storage temp.: 2-8°C
• SMILES string: Cl[H].CC(N)C(=O)Nc1c(C)cccc1C
• InChI: 1S/C11H16N2O.ClH/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12;/h4-6,9H,12H2,1-3H3,(H,13,14);1H
• InChI key: AMZACPWEJDQXGW-UHFFFAOYSA-N
• Gene Information: human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Description

Application

Tocainide hydrochloride may be used in cell signaling studies.

Biochem/physiol Actions

Tocainide hydrochloride is a primary amine analog of lidocaine (lignocaine), used for the treatment of tinnitus.[1] It blocks the sodium channels in the pain-producing foci in the nerve membranes and renders an analgesic effect in trigeminal neuralgia.[2]

Tocainide hydrochloride is a sodium channel blocker; Class IB antiarrhythmic.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Tocainide is voltage-dependent and use-dependent sodium channel blocker (class IB type antiarrhythmic); K_i = 115 μM in blockade of inactivated-state sodium channels; IC₅₀ = 985μM in blockade of Na+ currents at a holding potential (HP) of -140 mV; IC₅₀ = 254 μM in blockade of Na+ currents at HP -70 mV; IC₅₀ = 523 μM in blockade of Na+ currents at tonic block (-100 mV); IC₅₀ = 248 μM for use-dependent block at 10 Hz.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves