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SML2892

LY2584702 tosylate

≥98% (HPLC)

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Synonym(s):

4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine, 4-methylbenzenesulfonate (1:1), LY 2584702 tosylate, LY 2779964, LY-2584702 tosylate, LY-2779964, LY2779964, LYS6K2 tosylate

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Size/SKUAvailabilityPrice
5 mg
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2 380,00 CZK
25 mg
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7 740,00 CZK

About This Item

Empirical Formula (Hill Notation):
C21H19F4N7 · C7H8O3S
CAS Number:
1082949-68-5
Molecular Weight:
617.62
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD29054739
Assay:
≥98% (HPLC)
Form:
powder

2 380,00 CZK

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(F)c2c(ccc(c2)c3nc([n](c3)C)C4CCN(CC4)c5ncnc6n[nH]cc65)F.[S](=O)(=O)(O)c1ccc(cc1)C

InChI

1S/C21H19F4N7.C7H8O3S/c1-31-10-17(13-2-3-16(22)15(8-13)21(23,24)25)29-19(31)12-4-6-32(7-5-12)20-14-9-28-30-18(14)26-11-27-20;1-6-2-4-7(5-3-6)11(8,9)10/h2-3,8-12H,4-7H2,1H3,(H,26,27,28,30);2-5H,1H3,(H,8,9,10)

InChI key

HDYUXDNMHBQKAU-UHFFFAOYSA-N

Biochem/physiol Actions

LY2584702 is an orally active, ATP-competitive, potent and selective ribosomal protein S6 kinase (p70 S6 kinase, p70S6K, S6K1) inhibitor (IC50 = 4 nM; selective over 83 other kinases and 45 cell surface markers). LY2584702 inhibits HCT116 cellular S6 phosphorylation (IC50 0.1-0.24 μM) and shows anti-tumor efficacy in U87MG glioblastoma and HCT116 colon carcinoma xenograft models in vivo (2.5 mg/kg bid. po.).
Orally active, ATP-competitive, potent and selective ribosomal protein S6 kinase (p70 S6 kinase, p70S6K, S6K1) inhibitor with in vivo anti-tumor efficacy.

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LY2584702 tosylate ≥98% (HPLC)

Sigma-Aldrich

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LY2955303 ≥98% (HPLC)

Sigma-Aldrich

SML2183

LY2955303

Sorafenib tosylate ≥98% (HPLC)

Sigma-Aldrich

SML2633

Sorafenib tosylate

Pyr10 ≥98% (HPLC)

Sigma-Aldrich

SML1243

Pyr10

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

white to beige

color

white to very dark brown

color

white to beige

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000110764
0000102945
0000110765

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