SML1243
Pyr10
≥98% (HPLC)
Synonym(s):
N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-benzenesulfonamide
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 2 950,00 CZK |
25 mg | Please contact Customer Service for Availability | 9 360,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C18H13F6N3O2S
CAS Number:
Molecular Weight:
449.37
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
FC(F)(F)c1[n](nc(c1)C(F)(F)F)c2ccc(cc2)N[S](=O)(=O)c3ccc(cc3)C
InChI key
CVALMMCIOLXHDM-UHFFFAOYSA-N
Biochem/physiol Actions
Pyr10 is a novel, selective inhibitor of the transient receptor potential channel TRPC3.
Pyr10 is a novel, selective inhibitor of the transient receptor potential channel TRPC3. Pyr10 blocks carbachol-induced calcium entry into TRPC3-transfected HEK293 cells (IC50 = 0.72 μM), with significantly lower activity against STIM1/Orai1 mediated release of calcium from endoplasmic reticulum (store operated calcium entry) in BRL-2H3 cells (IC50 = 13.08 μM).
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description - | description affinity isolated antibody, lyophilized powder | description clone 10H6, from mouse |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - | assay - |
| form powder | form solid, semisolid | form lyophilized powder | form - |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. - |
| solubility DMSO: 20 mg/mL, clear | solubility DMSO: 100 mg/mL | solubility - | solubility - |
| color white to beige | color white to off-white, orange-brown | color - | color - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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