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SML2402

Sigma-Aldrich

WYC-209

≥98% (HPLC)

Synonym(s):

2-[2-(3,4-Dihydro-4,4-dimethyl-1-oxido-2H-1-benzothiopyran-6-yl)ethynyl-5-pyrimidinecarboxylic acid, ethyl ester

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5 MG
CZK 1,624.00
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CZK 5,327.00

CZK 1,624.00

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5 MG
CZK 1,624.00
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CZK 5,327.00

About This Item

Empirical Formula (Hill Notation):
C20H20N2O3S
CAS Number:
2131803-90-0
Molecular Weight:
368.45
UNSPSC Code:
12352200
NACRES:
NA.77

CZK 1,624.00

List PriceCZK 2,320.00Save 30%
Please contact Customer Service for Availability
Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=S1CCC(C)(C)C2=C1C=CC(C#CC3=NC=C(C(OCC)=O)C=N3)=C2

InChI key

LLMDAYVUHYVJSS-UHFFFAOYSA-N

Biochem/physiol Actions

Synthetic retinoid with antiproliferative activity
WYC-209 is a synthetic retinoid with antiproliferative activity and better inhibition of cancer cell growth and proliferation than Tazarotene or ATRA (all-trans-retinoic acid). WYC-209 was shown to inhibit proliferation of malignant murine melanoma tumor-repopulating cells (TRCs) with an IC50 value of 190 nM and also inhibited proliferation of TRCs of human melanoma, lung cancer, ovarian cancer, and breast cancer in culture.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Junwei Chen et al.
Nature communications, 9(1), 1406-1406 (2018-04-13)
Developing novel drugs that can abrogate the growth and metastasis of malignant tumors is a major challenge for cancer researchers. Here we describe a novel synthetic retinoid, namely WYC-209, which inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs), known

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