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SML1324

XEN445

≥98% (HPLC)

Synonym(s):

(S)-2-(3-(Pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid

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Size/SKUAvailabilityPrice
25 mg
Please contact Customer Service for Availability
9 620,00 CZK

About This Item

Empirical Formula (Hill Notation):
C18H17F3N2O3
CAS Number:
Molecular Weight:
366.33
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

9 620,00 CZK


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cc(c(cc1)N2C[C@H](CC2)OCc3ncccc3)C(=O)O

InChI

1S/C18H17F3N2O3/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)/t14-/m0/s1

InChI key

NBGRERFNOKZQLO-AWEZNQCLSA-N

Biochem/physiol Actions

XEN445 is a potent and selective inhibitor of endothelial lipase with an IC50 of 237 nM and high selectivity over hepatic and lipoprotein lipases. In experiments with wild-type mice, XEN445 raised plasma HDL-cholesterol levels by 16% after 3 days and by 30% after 9 days dosing.
XEN445 is a potent and selective inhibitor of endothelial lipase.

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This Item
SML0912SML2834A3111
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC), powder

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ≥10 mg/mL

color

white to beige

color

white to beige

color

white to beige

color

off-white


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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