SML0761

Gossypin

≥90% (HPLC)

• Synonym(s): 2-(3,4-Dihydroxyphenyl)-8-(β-D-glucopyranosyloxy)-3,5,7-trihydroxy- 4H-1-benzopyran-4-one, 3,3′,4′,5,7,8-Hexahydroxyflavone 8-glucoside, Gossypetin 8-glucoside
• Empirical Formula (Hill Notation): C₂₁H₂₀O₁₃
• CAS Number: 652-78-8
• Molecular Weight: 480.38
• NACRES: NA.77
• PubChem Substance ID: 329825593
• UNSPSC Code: 12352200
• MDL number: MFCD00017429
• Assay: ≥90% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• biological source: Hibiscus vitifolius
• assay: ≥90% (HPLC)
• form: powder
• storage condition: desiccated
• color: , light yellow to dark green-yellow
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: −20°C
• SMILES string: OC[C@H]1O[C@@H](Oc2c(O)cc(O)c3C(=O)C(O)=C(Oc23)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C21H20O13/c22-5-11-13(27)15(29)17(31)21(32-11)34-19-10(26)4-9(25)12-14(28)16(30)18(33-20(12)19)6-1-2-7(23)8(24)3-6/h1-4,11,13,15,17,21-27,29-31H,5H2/t11-,13-,15+,17-,21+/m1/s1
• InChI key: SJRXVLUZMMDCNG-KKPQBLLMSA-N

Description

General description

Gossypin has anti-inflammatory properties. It inhibits galactose-induced cataract formation and reduces β-amyloid-induced toxicity. Gossypin provides protection against carbon tetrachloride-induced toxicity and bis(2-choloroethyl) sulfide-induced dermal toxicity. It also induces apoptosis in myeloma cells. Gossypin has an anticonvulsant property.

Biochem/physiol Actions

Gossypin is an anti-inflammatory pentahydroxyflavone glucoside isolated from Hibiscus vitifolius that is used as an herbal remedy for diabetes, jaundice, and inflammation. Gossypin potently inhibits human cancer cell proliferation, including melanoma and glioma cells. Gossypin directly binds and inhibits BRAFV600E and CDK4 kinases, and also regulates Chk1 and Cdc25C in U251 glioma cells.

Gossypin is an anti-inflammatory pentahydroxyflavone glucoside that directly binds and inhibits BRAFV600E and CDK4 kinases.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable