SML0378

Ralfinamide mesylate

≥98% (HPLC)

• Synonym(s): (2S)-2-[[[4-[(2-Fluorophenyl)methoxy]phenyl]methyl]amino]-propanamide methanesulfonate
• Empirical Formula (Hill Notation): C₁₇H₁₉FN₂O₂ · CH₃SO₃H
• CAS Number: 202825-45-4
• Molecular Weight: 398.45
• NACRES: NA.77
• PubChem Substance ID: 329825378
• UNSPSC Code: 12352200
• MDL number: MFCD19690932
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D 10 to 15° (c=1 HOAc)
• color: white to beige
• solubility: H₂O: >15 mg/mL
• storage temp.: 2-8°C
• SMILES string: CS(O)(=O)=O.C[C@H](NCc1ccc(OCc2ccccc2F)cc1)C(N)=O
• InChI: 1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-6-8-15(9-7-13)22-11-14-4-2-3-5-16(14)18;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1
• InChI key: CHQVNINIGBRKGZ-YDALLXLXSA-N

Description

Biochem/physiol Actions

Ralfinamide is a mixed sodium and N-type calcium channel blocker.

Ralfinamide is a mixed sodium and N-type calcium channel blocker. Inhibiton is voltage-dependent, with higher potency against inactivated channels. Ralfinamide is two fold selective for tetrodotoxin (TTX)-resistant sodium channels compared with TTX-sensitive currents.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Codes: H301
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable