SML2657
MP-A08
≥98% (HPLC)
Synonym(s):
4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide, NSC-122314
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | CZK 2,440.00 CZK 2,074.00 |
25 mg | Please contact Customer Service for Availability | CZK 7,920.00 CZK 6,732.00 |
About This Item
Empirical Formula (Hill Notation):
C27H25N3O4S2
CAS Number:
Molecular Weight:
519.64
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
CZK 2,074.00
List PriceCZK 2,440.00Save 15%Please contact Customer Service for Availability
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(Nc2c(cccc2)\N=C\c3c(cccc3)N[S](=O)(=O)c4ccc(cc4)C)c1ccc(cc1)C
InChI key
FLDBNMYJUMAXDQ-TURZUDJPSA-N
Biochem/physiol Actions
ATP-competitive sphingosine kinase inhibitor that targets both SK1 and SK2 (SphK 1 and 2)
MP-A08 is a highly selective ATP-competitive sphingosine kinase inhibitor that targets both SK1 and SK2. It is more selective and acts by different mechanisms than other SK inhibitors. MP-A0 targets the ATP-binding pocket, rather than the sphingosine binding pocket, with Ki values of 6.9 and 27 μM, respectively. Also, both SKI-II and PF-543 are thought to act in part by targeting sphingosine kinase for proteasomal degradation, which is not the case with MP-A08. MP-A08 was found to suppress the growth of human lung tumor xenografts in mice, both inducing apoptosis and inhibiting angiogenesis.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 25 mg/mL, clear | solubility DMSO: 2 mg/mL, clear |
| color white to beige | color white to beige | color off-white to purple | color white to beige |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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