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| Size/SKU | Availability | Price |
|---|---|---|
25 mg | Please contact Customer Service for Availability | 9 700,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C13H12FN3O3S
CAS Number:
Molecular Weight:
309.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >15 mg/mL
storage temp.
2-8°C
SMILES string
O=C(NC1=CC=C(S(N)(=O)=O)C=C1)NC2=CC=C(F)C=C2
InChI
1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18)
InChI key
YJQZNWPYLCNRLP-UHFFFAOYSA-N
Biochem/physiol Actions
U-104 is a carbonic anhydrase IX (CAIX) inhibitor and a CAXII inhibitor.
U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.
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This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: >15 mg/mL | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: >15 mg/mL |
| color white to beige | color white to beige | color white to beige | color white to beige |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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