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SML0264

AEG 3482

≥98% (HPLC)

Promotion Available

Synonym(s):

6-Phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
2 760,00 CZK

About This Item

Empirical Formula (Hill Notation):
C10H8N4O2S2
CAS Number:
Molecular Weight:
280.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

2 760,00 CZK

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

faintly yellow to dark yellow

solubility

DMSO: ≥15 mg/mL

storage temp.

2-8°C

SMILES string

NS(=O)(=O)c1nn2cc(nc2s1)-c3ccccc3

InChI

1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16)

InChI key

MQUYTXDAVCOCMX-UHFFFAOYSA-N

Biochem/physiol Actions

AEG3284 is a compound that binds to heat shock protein 90 (HSP90), leading to heat shock factor 1 (HSF1) dependent expression of HSP70, an endogenous inhibitor of c-Jun N-terminal kinase (JNK) activity. Treatment of PC12 cells with AEF3284 blocks JNK dependent apoptosis.
AEG3284 is an indirect inhibitor of JNK activity; HSP90 binder.
AEG 3482 is an imidazothiadiazole sulfonamide of 281 D with an anti-apoptotic property.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
SML1806SML0136SML2593
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: ≥15 mg/mL

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: ≥8 mg/mL

solubility

DMSO: 2 mg/mL, clear

color

faintly yellow to dark yellow

color

white to light brown

color

white to tan

color

white to beige


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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