S7448
STF-62247
≥98% (HPLC), solid
Synonym(s):
N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
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About This Item
Empirical Formula (Hill Notation):
C15H13N3S
CAS Number:
Molecular Weight:
267.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
solid
solubility
DMSO: soluble 26 mg/mL, H2O: insoluble
storage temp.
room temp
SMILES string
Cc1cccc(Nc2nc(cs2)-c3ccncc3)c1
InChI
1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)
InChI key
KATNUHQNJGNLPW-UHFFFAOYSA-N
Application
STF-62247 may be used as positive control in autophagy inducing cell signaling studies.
Biochem/physiol Actions
STF-62247 induces the formation of large vacuoles in the von Hippel-Lindau deficient renal carcinoma cells, a characteristic of autophagy.1
STF-62247 is a selective inducer of autophagy in VHL-deficient renal cell carcinoma cells.
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This Item | |||
|---|---|---|---|
| form solid | form solid | form solid | form solid |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. room temp | storage temp. room temp | storage temp. 2-8°C | storage temp. room temp |
| solubility DMSO: soluble 26 mg/mL, H2O: insoluble | solubility DMSO: 26 mg/mL | solubility DMSO: 50 mg/mL | solubility DMSO: ≥28 mg/mL |
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
Storage Class
11 - Combustible Solids
wgk
WGK 2
ppe
dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
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Tomohiro Kozako et al.
BMC cancer, 18(1), 791-791 (2018-08-08)
Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide+-dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 expression increases in acute myeloid leukemia blasts. Downregulation of SIRT2 using siRNA causes apoptosis
Sandra Turcotte et al.
Autophagy, 4(7), 944-946 (2008-09-05)
Radiation and conventional cytotoxic chemotherapies are ineffective in treating renal cancer. Approximately 75 percent of renal cell carcinoma (RCC) is associated with an inactivation of the tumor suppressor gene von Hippel-Lindau (VHL). We exploited the possibility of targeting VHL-deficient RCC
Kanchan Phadwal et al.
Autophagy, 8(4), 677-689 (2012-02-04)
Autophagy is a conserved constitutive cellular process, responsible for the degradation of dysfunctional proteins and organelles. Autophagy plays a role in many diseases such as neurodegeneration and cancer; however, to date, conventional autophagy detection techniques are not suitable for clinical
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S7448-5MG | 04061833221402 |