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S6508
Sodium orthovanadate
synthetic (organic), ≥90% (titration), protein tyrosine phosphatase inhibitor, crystalline powder
Synonym(s):
Trisodium vanadate
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| Size/SKU | Availability | Price |
|---|---|---|
10 g | Please contact Customer Service for Availability | CZK 2,050.00 |
50 g | Please contact Customer Service for Availability | CZK 3,660.00 |
250 g | Please contact Customer Service for Availability | CZK 13,500.00 |
About This Item
Linear Formula:
Na3VO4
CAS Number:
Molecular Weight:
183.91
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
237-287-9
MDL number:
Assay:
≥90% (titration)
Form:
crystalline powder
Product Name
Sodium orthovanadate, ≥90% (titration)
biological source
synthetic (organic)
Quality Segment
assay
≥90% (titration)
form
crystalline powder
reaction suitability
reagent type: catalyst
core: vanadium
color
white to off-white
mp
850-866 °C (lit.)
solubility
H2O: soluble
SMILES string
[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O
InChI
1S/3Na.4O.V/q3*+1;;3*-1;
InChI key
IHIXIJGXTJIKRB-UHFFFAOYSA-N
Application
Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase.26 It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.27
Biochem/physiol Actions
Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release from endocrine cells and blocks IP3 binding to its receptor in brain tissue.
Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.24 In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.25
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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This Item | |||
|---|---|---|---|
| form crystalline powder | form solid | form solid | form powder |
| assay ≥90% (titration) | assay - | assay 99.98% trace metals basis | assay ≥90% (HPCE) |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
| solubility H2O: soluble | solubility water: 10 mg/mL | solubility - | solubility DMF: soluble, DMSO: soluble, H2O: soluble, methanol: soluble |
| color white to off-white | color white to off-white | color - | color - |
| biological source synthetic (organic) | biological source - | biological source - | biological source - |
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signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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What is the Department of Transportation shipping information for this product?
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How do I prepare solutions of Product S6508, Sodium Orthovanadate?
1 answer-
Solutions of Product S6508, Sodium Orthovanadate, prepared as 1 mM in water (or higher if desired) and adjusted down to pH 10 can be aliquotted in plastic tubes and stored at -20°C. To ensure the presence of monomers, solutions should be heated to boiling until translucent and pH readjusted to 10. View the product information sheet (under Documents, above), which has more details.
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Which enzymes does S6508 inhibit?
1 answer-
Sodium orthovanadate is an inhibitor of ATPase, alkaline phosphatase and tyrosine phosphatase.
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What is the amount of S6508, Sodium orthovanadate, needed for inhibition?
1 answer-
For ATPase, a 0.5-1 μM concentration of sodium orthovanadate inhibited 50% of the activity. Please see the product information sheet (under Documents, above) which provides references on several other enzymes.
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How do I store solutions of Product S6508, Sodium Orthovanadate?
1 answer-
Solutions of Product S6508, Sodium Orthovanadate, prepared as 1 mM in water (or higher if desired) and adjusted down to pH 10 can be aliquotted in plastic tubes and stored at -20°C. To ensure the presence of monomers, solutions should be heated to boiling until translucent and pH readjusted to 10. View the product information sheet (under Documents, above), which has more details.
Helpful?
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