567540

Sodium Orthovanadate

A broad spectrum potent inhibitor of protein tyrosine phosphatases.

• Synonym(s): Sodium Orthovanadate, PTP Inhibitor X
• Empirical Formula (Hill Notation): Na₃O₄V
• CAS Number: 13721-39-6
• Molecular Weight: 183.91
• UNSPSC Code: 12352202
• NACRES: NA.77
• MDL number: MFCD00003511
• Form: solid
• Storage condition: OK to freeze

Properties

• Quality Segment: 100
• description: RTECS - YW1120000
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to off-white
• solubility: water: 10 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: [V](=O)([O-])([O-])[O-].[Na+].[Na+].[Na+]
• InChI: 1S/3Na.4O.V/q3*+1;;3*-1;
• InChI key: IHIXIJGXTJIKRB-UHFFFAOYSA-N

Description

General description

A broad spectrum potent inhibitor of protein tyrosine phosphatases. Also known to inhibit Na⁺/K⁺ ATPase, acid and alkaline phosphatases, phosphofructokinase, and adenylate kinase. Most recently shown to inhibit ATPase activity of the reconstituted binding protein-dependent ATP-Binding Cassette (ABC) transporter for maltose (MalFGK₂) of Salmonella typhimurium in the micromolar range. Can be converted to pervanadate by hydrogen peroxide.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Na⁺,K⁺-ATPase, acid , alkaline phosphatases, phosphofructokinase, and adenylate kinase

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Huyer, G., et al. 1997. J. Biol. Chem. 272, 843.
Hunke, S., et al. 1995. Biochem. Biophys. Res. Commun.216, 589.
Levchuck, S.G., et al. 1994. Pediatric Res.37, 382A.
Fohr, K.J., et al. 1989. Biochem. J.262, 83.
Swarup, G., et al. 1982. Biochem. Biophys. Res. Commun.107, 1104.
Seargeant, L.E. and Stinson, R.A. 1979. Biochem. J.181, 247.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332,H315,H319
• pcodes: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable