As mentioned in the 'PROPERTIES' section, this product can be solubilized in chloroform at 50 mg/mL. In addition, this material is also soluble in DMSO at 5 mg/mL. DMSO stock solutions are stable for at least 6 months at -20°C. Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/140/282/r7772pis.pdf
R7772
Roscovitine
synthetic (organic), ≥98% (TLC), cyclin-dependent kinases inhibitor, powder
Synonym(s):
2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
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| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Please contact Customer Service for Availability | CZK 2,790.00 |
5 mg | Please contact Customer Service for Availability | CZK 9,680.00 |
About This Item
Empirical Formula (Hill Notation):
C19H26N6O
CAS Number:
Molecular Weight:
354.45
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (TLC)
Form:
powder
Product Name
Roscovitine, ≥98% (TLC)
biological source
synthetic (organic)
Quality Segment
assay
≥98% (TLC)
form
powder
mp
106-107 °C
solubility
chloroform: 50 mg/mL, clear, colorless to light yellow
storage temp.
−20°C
SMILES string
CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1
InChI
1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
InChI key
BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Gene Information
human ... CDK1(983), CDK2(1017), CDK5(1020), CDK7(1022), CDK9(1025), CDKN1A(1026), CDKN1B(1027), CDKN1C(1028), CDKN2A(1029), CDKN2B(1030), CDKN2C(1031), CDKN2D(1032), CDKN3(1033)
mouse ... CDK1(12534)
rat ... CDK1(54237)
Application
Roscovitine has been used:
- an inhibitor of p34cdc2/cyclin B kinase to preculture porcine oocytes
- as a supplement in TCM199 medium for in vitro prematuration of cumulus-oocyte complexes (COCs) of adult goats
- in astrocyte conditioned media as an inhibitor of cyclin-dependent kinase 5 (CDK5)[1]
- as a CDK2 inhibitor in culture media to treat hESCs
Biochem/physiol Actions
Roscovitine is a purine derived inhibitor. It stimulates apoptosis in cancer cells. It has inhibitory action on mitogen activated protein kinase (MAPK) and M-phase promoting factor (MPF) kinase activity. Roscovitine is known to arrest meiosis and thus, prevent embryonic development.
Roscovitine is a potent, selective inhibitor of cyclin-dependent kinases.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Legal Information
Sold under license from CNRS
1 of 1
This Item | |||
|---|---|---|---|
| form powder | form powder | form solid | form solid |
| assay ≥98% (TLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥97% (HPLC) |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level - |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| solubility chloroform: 50 mg/mL, clear, colorless to light yellow | solubility DMSO: ≥10 mg/mL | solubility DMSO: 10 mg/mL | solubility DMSO: soluble 37 mg/mL, H2O: insoluble |
| mp 106-107 °C | mp - | mp - | mp - |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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In what solvent and at what concentration do I reconstitute Roscovitine (R7772) ?
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