The solubility in PBS has not been evaluated, and additional stability studies following reconstitution have not been conducted. According to the datasheet, storage should be in a tightly sealed container at room temperature, and the product is soluble in water at 89 mg/ml. More information can be found in the document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/363/806/r121dat.pdf. According to established guidelines, the stock solution should be stored as follows: at -80 °C, it is recommended to use the solution within 6 months; at -20 °C, it should be used within 1 month.
R121
S(−)-Raclopride (+)-tartrate salt
>97%, Dopamine D2 receptor antagonist, solid
Synonym(s):
3,5-Dichloro-N-(1-ethylpyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxybenzamide (+)-tartrate salt
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 25 mg | Please contact Customer Service for Availability | CZK 4,790.00 | |
| 100 mg | Please contact Customer Service for Availability | CZK 14,200.00 |
About This Item
Empirical Formula (Hill Notation):
C15H20Cl2N2O3 · C4H6O6
CAS Number:
Molecular Weight:
497.32
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
>97%
Form:
solid
Product Name
S(−)-Raclopride (+)-tartrate salt, >97%, solid
Quality Segment
assay
>97%
form
solid
color
white
solubility
H2O: 89 mg/mL
SMILES string
O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN1CCC[C@H]1CNC(=O)c2c(O)c(Cl)cc(Cl)c2OC
InChI
1S/C15H20Cl2N2O3.C4H6O6/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2;5-1(3(7)8)2(6)4(9)10/h7,9,20H,3-6,8H2,1-2H3,(H,18,21);1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1
InChI key
QULBVRZTKPQGCR-NDAAPVSOSA-N
Gene Information
human ... DRD2(1813)
Application
S(−)-Raclopride (+)-tartrate salt has been used as a D2 receptor antagonist:
- to study the role of the D2 receptor in mediating ventrolateral PAG (vlPAG)/dorsal raphe dopaminergic antinociceptive effect in animals
- in pharmacological and behavioral studies performed with Thap1 null mice
- to determine the relationship between Ca2+ transients and dopamine neuron activity in rats
Biochem/physiol Actions
Raclopride is a benzamide derivative and a selective D2 dopamine receptor antagonist.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Disclaimer
Photosensitive
1 of 1
This Item | |||
|---|---|---|---|
| form solid | form powder | form solid | form solid |
| assay >97% | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| solubility H2O: 89 mg/mL | solubility H2O: soluble >10 mg/mL, ethanol: soluble 2.6 mg/mL, 0.1 M HCl: soluble 7 mg/mL | solubility H2O: 10 mg/mL | solubility H2O: 13 mg/mL |
| color white | color off-white | color white | color white |
| Gene Information human ... DRD2(1813) | Gene Information human ... DRD2(1813) | Gene Information - | Gene Information human ... OPRK1(4986) |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
Datasheet
Global Trade Item Number
| SKU | GTIN |
|---|---|
| R121-25MG | 04061836694272 |
| R121-100MG | 04061832093147 |
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If a stock solution of raclopride tartrate is made in PBS, can this be stored aliquoted in -20°C? If so, for how long can this be stored?
1 answer-
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