P7867
Prostaglandin H2
≥95% (HPLC), acetonitrile solution
Synonym(s):
Endoperoxide H2, PGH2, Prostaglandin R2
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About This Item
Empirical Formula (Hill Notation):
C20H32O5
CAS Number:
Molecular Weight:
352.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-835-2
MDL number:
assay
≥95% (HPLC)
form
acetonitrile solution
shipped in
dry ice
storage temp.
−70°C
SMILES string
CCCCC[C@H](O)\C=C\[C@H]1C2CC(OO2)[C@@H]1C\C=C/CCCC(O)=O
InChI
1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
InChI key
YIBNHAJFJUQSRA-YNNPMVKQSA-N
Biochem/physiol Actions
Aryl hydrocarbon receptor (AhR) ligand and activator of the AhR signal transduction pathway. Also acts as a modest ligand of the peroxisome proliferator-activated receptor (PPAR-γ).
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
Storage Class
3 - Flammable liquids
wgk
WGK 2
flash_point_f
1.4 °F - closed cup
flash_point_c
-17 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Related Content
P Gresele et al.
Trends in pharmacological sciences, 12(4), 158-163 (1991-04-01)
Thromboxane A2 (TXA2) plays a pivotal role in platelet activation and is involved in the development of thrombosis. Thromboxane synthase inhibitors suppress TXA2 formation and increase the synthesis of the antiaggregatory prostaglandins PGI2 and PGD2; however, accumulated PGH2 may interact
O V Miller et al.
Prostaglandins, 13(4), 599-609 (1977-04-01)
The prostaglandin endoperoxide PGH2, HHT, HETE, thromboxane A2, and thromboxane B2, which are all products of arachidonic acid metabolism of human platelets, were tested for their ability to modulate platelet cyclic nucleotide levels. None of the compounds tested altered the
H Patscheke et al.
Zeitschrift fur Kardiologie, 79 Suppl 3, 151-154 (1990-01-01)
The formation of the proischemic and prothrombotic thromboxane A2 (TXA2) and of its functional antagonist prostacyclin is increased in patients with unstable angina and myocardial infarction. Therefore, pharmacological interventions aim at an inhibition of the synthesis or action of TXA2