This product is also soluble in water at 10mg/ml. Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/195/258/p4020pis.pdf
P4020
Protamine sulfate
amorphous powder
Synonym(s):
Salmine, Salmine from salmon
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| Size/SKU | Availability | Price |
|---|---|---|
1 g | Please contact Customer Service for Availability | 1 420,00 CZK |
5 g | Please contact Customer Service for Availability | 2 470,00 CZK |
10 g | Please contact Customer Service for Availability | 5 680,00 CZK |
25 g | Please contact Customer Service for Availability | 11 300,00 CZK 9 605,00 CZK |
100 g | Please contact Customer Service for Availability | 37 700,00 CZK 32 045,00 CZK |
About This Item
Product Name
Protamine sulfate salt from salmon, Grade X, amorphous powder
type
Grade X
Quality Segment
form
amorphous powder
impurities
histone, free (Millon test)
color
white to off-white
solubility
6 M HCl: 25 mg/mL
General description
Protamine are proteins rich in cysteine and arginine. It possesses many phosphorylation sites. It is found to be localized to the sperm head.
Application
Protamine sulfate salt from salmon has been used:
- in the pretreament of cells to study its effect on respiratory syncytial virus infection
- in lentivirus production
- to derivatize it into a diazeniumdiolate NO donor
May be used for the removal of DNA from protein samples or for the purification of DNA binding proteins. It may be used as an alternative to polybrene in retroviral-mediated gene transfer.
Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Protamine in the form of solid lipid nanoparticles (SLN) promoted transfection with plasmid DNA more efficiently and with less cytotoxicity than comparable SLNs composed of Esterquat-1.
Biochem/physiol Actions
Protamine sulfate is a small cationic protein that binds and precipitates DNA. Neutralizes the anticoagulant activity of heparin. Inhibits lipoprotein lipase.
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This Item | |||
|---|---|---|---|
| description Grade X, amorphous powder | description Grade II | description meets USP testing specifications | description Grade III, histone, free(Millon test) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form amorphous powder | form powder | form solid | form powder |
| solubility 6 M HCl: 25 mg/mL | solubility 6 M HCl: 25 mg/mL, clear, colorless to light yellow | solubility - | solubility 6 M HCl: 25 mg/mL, clear, colorless to very faintly yellow |
| color white to off-white | color white to off-white | color - | color - |
| type Grade X | type Grade II | type - | type Grade III |
| impurities histone, free (Millon test) | impurities - | impurities - | impurities histone, free (Millon test) |
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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Are there other solvents besides 6M HCl to bring protamine sulfate salt into solution?
1 answer-
Helpful?
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Bonjour, Pourriez vous me confirmer qu'il s'agit bien d'un polypeptide et de combien d'unité de monomère est il formé ? Pourriez vous m'envoyer la représentation de la molécule ? merci
1 answer-
Unfortunately, structural studies on for this product have not been performed. However, regarding structure characterization and molecular representation of protamine from salmon, the following publication may be of interest for reference.
J Biol Chem. 1959 Sep:234:2314-6.
Physical and chemical properties of protamine from the sperm of salmon (Oncorhynchus tschawytscha). II. Anion binding characteristics
https://pubmed.ncbi.nlm.nih.gov/13807973/Helpful?
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