P3075

Phenylarsine oxide

synthetic (organic), ≥97%, tyrosine phosphatase inhibitor, powder

• Synonym(s): Arzene, Oxophenylarsine, PAO
• Empirical Formula (Hill Notation): C₆H₅AsO
• CAS Number: 637-03-6
• Molecular Weight: 168.02
• NACRES: NA.77
• PubChem Substance ID: 24898387
• UNSPSC Code: 12352119
• EC Number: 211-275-3
• MDL number: MFCD00001990
• Beilstein/REAXYS Number: 2935227
• Assay: ≥97%
• Form: powder

Properties

• Product Name: Phenylarsine oxide, ≥97%, powder
• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥97%
• form: powder
• color: white to off-white
• mp: 145-148 °C
• solubility: DMSO: 50 mg/mL
• SMILES string: O=[As]c1ccccc1
• InChI: 1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H
• InChI key: BQVCCPGCDUSGOE-UHFFFAOYSA-N

Description

General description

Phenylarsine oxide (PhAsO⁴) is a bifunctional SH group chemical. It is hydrophobic in nature.

Application

Phenylarsine oxide has been used to infuse animals with a nigrostriatal transection, to determine whether peroxovanadium (pVa) would synergize with brain-derived neurotrophic factor (BDNF).

Biochem/physiol Actions

Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.

Phenylarsine oxide (PAO) can reduce the motility and sustainability of Setaria cervi. It has the ability to stimulate cyclosporin A-sensitive transition in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid). It acts as a stimulator of mitochondrial ion fluxes.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H301 + H331,H410
• pcodes: P261 - P264 - P271 - P273 - P301 + P310 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable