P1319

Thyrotropin releasing hormone

≥98% (HPLC), powder

• Synonym(s): L-Pyroglutamyl-L-histidyl-L-prolinamide, TRF, TRH, Thyroliberin, pGlu-His-Pro amide
• Empirical Formula (Hill Notation): C₁₆H₂₂N₆O₄
• CAS Number: 24305-27-9
• Molecular Weight: 362.38
• UNSPSC Code: 51111800
• NACRES: NA.32
• PubChem Substance ID: 24898185
• EC Number: 246-143-4
• Beilstein/REAXYS Number: 770238
• MDL number: MFCD00038640

Properties

• biological source: human
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• mol wt: 362.38
• storage condition: (Keep container tightly closed in a dry and well-ventilated place)
• technique(s): activity assay: suitable
• impurities: 22.6-23.8% Nitrogen, 51.9-54.1% carbon
• solubility: water: 25 mg/mL, cloudy, colorless to faintly yellow
• UniProt accession no.: P20396, P21761, P34981
• storage temp.: −20°C
• SMILES string: NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]3CCC(=O)N3
• InChI: 1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
• InChI key: XNSAINXGIQZQOO-SRVKXCTJSA-N
• Gene Information: human ... TRH(7200), TRHR(7201) ; mouse ... Trhr(22045)

Description

General description

Research area: Cell Signaling
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.[1]

Application

Thyrotropin-releasing hormone has been used as a media supplement to study its effects on stimulating the secretion of prolactin (PRL) from somatolactotroph GH3 cells by enzyme immunometric assay.[2] It has also been used to study its effects on the regulation of energy homeostasis in the central nervous system (CNS) in response to essential amino-acid deprivation.[3]

Biochem/physiol Actions

Thyrotropin releasing hormone (TRH) stimulates production and secretion of thyrotropin (TSH) and prolactin from the anterior pituitary.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.[4]TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol.[5] TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.[1]

Stimulates the production of thyrotropin (TSH) and its secretion from the anterior pituitary.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)