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Phaclofen

Name: Phaclofen
Brand: SIGMA
Price: 3300 CZK

solid

Synonym(s):

3-Amino-2-(4-chlorophenyl)propanephosphonic acid

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Pack Size	Availability	Price
5 mg	Please contact Customer Service for Availability	CZK 3,300.00
25 mg	Please contact Customer Service for Availability	CZK 12,500.00 CZK 10,625.00
100 mg	Please contact Customer Service for Availability	CZK 38,100.00

About This Item

Empirical Formula (Hill Notation):

C₉H₁₃ClNO₃P

CAS Number:

114012-12-3

Molecular Weight:

249.63

NACRES:

NA.32

PubChem Substance ID:

24278189

UNSPSC Code:

12352200

MDL number:

MFCD00069328

CZK 3,300.00

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Properties

form

solid

Quality Segment

100

impurities

≥97% (NMR)

color

white

solubility

0.1 M HCl: 13.3 mg/mL, methanol: 19.3 mg/mL, DMSO: insoluble

SMILES string

NCC(CP(O)(O)=O)c1ccc(Cl)cc1

InChI

1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14)

InChI key

VSGNGLJPOGUDON-UHFFFAOYSA-N

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Description

General description

Phaclofen is a phosphonic acid derivative of baclofen.

Application

Phaclofen has been used to block GABAB receptor.

Biochem/physiol Actions

Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (−) baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K⁺dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.

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This Item	A6566	S166	PHR8947
Sigma-Aldrich P118 Phaclofen	Sigma-Aldrich A6566 2-Hydroxysaclofen	Sigma-Aldrich S166 Saclofen	Supelco PHR8947 Baclofen Related Compound A
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 300
form solid	form solid	form solid	form powder
Gene Information human ... GABBR1(2550), GABBR2(9568)	Gene Information human ... GABBR1(2550), GABBR2(9568)	Gene Information human ... GABBR1(2550), GABBR2(9568) mouse ... GABBR1(54393), GABBR2(242425) rat ... GABBR1(81657), GABBR2(83633)	Gene Information -
impurities ≥97% (NMR)	impurities -	impurities -	impurities -
color white	color white	color white	color -
solubility 0.1 M HCl: 13.3 mg/mL, DMSO: insoluble, methanol: 19.3 mg/mL	solubility H₂O: 1 mg/mL, 0.1 M HCl: 1.2 mg/mL, methanol: 1.4 mg/mL, DMSO: 28 mg/mL, 0.1 M NaOH: 9.5 mg/mL	solubility 0.1 M NaOH: 20 mg/mL	solubility -