P0036

PP121

≥98% (HPLC)

• Synonym(s): 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
• Empirical Formula (Hill Notation): C₁₇H₁₇N₇
• CAS Number: 1092788-83-4
• Molecular Weight: 319.36
• NACRES: NA.77
• PubChem Substance ID: 329819987
• UNSPSC Code: 12352200
• MDL number: MFCD12912434
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• assay: ≥98% (HPLC)
• form: powder
• color: off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Nc1ncnc2n(nc(-c3cnc4[nH]ccc4c3)c12)C5CCCC5
• InChI: 1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22)
• InChI key: NVRXTLZYXZNATH-UHFFFAOYSA-N

Description

Biochem/physiol Actions

PP121 blocks the vascular endothelial growth factor (VEGF) receptor and its related signaling events.[1] It also inhibits tumor cell proliferation by targeting oncogenic tyrosine kinase and phosphoinositide 3-kinases (PI3Ks).[1]

PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases.

PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases. PP121 is the first inhibitor active on both Tyrosine kinases and the phosphatidylinositol-3-OH kinase (PI(3)K) family. The inhibitor is not effecting other serine-threonine protein kinases.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable