P0042
PP2
≥98% (HPLC), Src-family tyrosine kinase inhibitor, powder
Synonym(s):
4-Amino-3-(4-chlorophenyl)-1-(t-butyl)-1H-pyrazolo[3,4-d]pyrimidine, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine, AG 1879
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | 5 210,00 CZK |
About This Item
Product Name
PP2, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
CC(C)(C)n1nc(-c2ccc(Cl)cc2)c3c(N)ncnc13
InChI
1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
InChI key
PBBRWFOVCUAONR-UHFFFAOYSA-N
Application
- to analyze the effects of Src/focal adhesion kinase (FAK) signaling on IQ domain GTPase-activating protein 1 (IQGAP1)-mediated anoikis resistance
- for Src inhibition to study its effect on epidermal growth factor receptor (EGFR) and nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation in non-small cell lung cancer (NSCLC) cells
- for pharmacological inhibition of SRC in MDA-MB-231 breast cancer cells
Biochem/physiol Actions
Features and Benefits
1 of 1
This Item | ||
|---|---|---|
| description ≥98% (HPLC) | description PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC50 = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively). | description InSolution, ≥95%, 10 mM, reversible ATP-competitive inhibitor of the Src family of protein tyrosine kinases |
| form powder | form solid | form liquid |
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: >10 mg/mL | solubility DMSO: 20 mg/mL | solubility - |
| color white to off-white | color off-white | color clear colorless |
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Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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