N8534

Nilutamide

solid

• Synonym(s): 5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione, Anandron, RU-23908
• Empirical Formula (Hill Notation): C₁₂H₁₀F₃N₃O₄
• CAS Number: 63612-50-0
• Molecular Weight: 317.22
• NACRES: NA.77
• PubChem Substance ID: 24278596
• UNSPSC Code: 51111800
• MDL number: MFCD00864670
• Form: solid

Properties

• form: solid
• Quality Segment: 200
• originator: Sanofi Aventis
• SMILES string: CC1(C)NC(=O)N(c2ccc(c(c2)C(F)(F)F)[N+]([O-])=O)C1=O
• InChI: 1S/C12H10F3N3O4/c1-11(2)9(19)17(10(20)16-11)6-3-4-8(18(21)22)7(5-6)12(13,14)15/h3-5H,1-2H3,(H,16,20)
• InChI key: XWXYUMMDTVBTOU-UHFFFAOYSA-N
• Gene Information: human ... AR(367)

Description

Application

Nilutamide has been used:

• as a nuclear androgen receptor (nAR) inhibitor to study its effects on oocyte maturation in zebrafish[1]
• to determine its effects on bioluminescent Saccharomyces cerevisiae bioreporters in BLYAS assay[2]
• as a substrate in hydrogenation reaction[3]

Biochem/physiol Actions

Nilutamide is a nuclear androgen receptor inhibitor.[1] It is a nonsteroidal antiandrogen that competitively inhibits the binding of dihydrotestosterone to the androgen receptor.[4] Nilutamide shows a therapeutic effect against prostate cancer.[5]

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H360
• pcodes: P201 - P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral - Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges