This product may be stored at room temperature. For products with no specified storage temperature given on the label or product page, ambient storage may be assumed. Products that require controlled temperature storage, such as refrigeration or freezer conditions, storage temperatures are published on the product label, Certificate of Analysis, the Safety Data Sheet (SDS), and in the PROPERTIES section of the product detail page.
N171
NBQX hydrate
powder, ≥98% (HPLC)
Synonym(s):
1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate, FG 9202
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 mg | Please contact Customer Service for Availability | CZK 6,830.00 | |
| 25 mg | Please contact Customer Service for Availability | CZK 27,900.00 CZK 23,715.00 |
About This Item
Empirical Formula (Hill Notation):
C12H8N4O6S · xH2O
CAS Number:
Molecular Weight:
336.28 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
methanol: 0.25 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.5 mg/mL, DMSO: 4 mg/mL, H2O: insoluble
SMILES string
O.NS(=O)(=O)c1cccc2c3NC(=O)C(=O)Nc3cc([N+]([O-])=O)c12
InChI
1S/C12H8N4O6S.H2O/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);1H2
InChI key
VOYWRRFTJLCIEL-UHFFFAOYSA-N
General description
NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline] is a competitive antagonist, which shows high affinity to 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA) receptor than kainite receptor.
Application
NBQX hydrate has been used:
- as a non-N-methyl-D-aspartate receptor (NMDA) 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA) receptor antagonist to monitor gonadotropin responses[1]
- α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) antagonist in monocytes
- AMPA and N-methyl-D-aspartate receptor (NMDA) antagonist in migrating interneurons expressing potassium-chloride cotransporter (shKCC2)
Biochem/physiol Actions
NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline], an anticonvulsant provides protection against white matter damage in spinal cord crush injury and also protects oligodendrocyte in experimental autoimmune encephalomyelitis (EAE). However, its role in preventing inflammation in EAE is not yet clear.
Neuroprotective AMPA/kainate glutamate receptor antagonist.
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This Item | |||
|---|---|---|---|
| form powder | form lyophilized powder | form solid | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| solubility methanol: 0.25 mg/mL, DMSO: 4 mg/mL, H2O: insoluble, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.5 mg/mL | solubility H2O: >10 mg/mL | solubility H2O: >2 mg/mL (warmed) | solubility water: 10 mg/mL |
| color yellow | color , brown to dark red-brown | color orange to red | color white to beige |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Pro-inflammatory monocyte profile in patients with major depressive disorder and suicide behaviour and how ketamine induces anti-inflammatory M2 macrophages by NMDAR and mTOR
Nowak W, et al.
EBioMedicine, 50, 290-305 (2019)
Jane E Libbey et al.
Experimental neurology, 280, 89-96 (2016-04-14)
Seizures occur due to an imbalance between excitation and inhibition, with the balance tipping towards excitation, and glutamate is the predominant excitatory neurotransmitter in the central nervous system of mammals. Since upregulation of expression and/or function of glutamate receptors can
D Pitt et al.
Nature medicine, 6(1), 67-70 (1999-12-29)
Glutamate excitotoxicity mediated by the AMPA/kainate type of glutamate receptors damages not only neurons but also the myelin-producing cell of the central nervous system, the oligodendrocyte. In multiple sclerosis, myelin, oligodendrocytes and some axons are lost as a result of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| N171-5MG | 04061834109723 |
| N171-25MG | 04061832092232 |
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Hello. How to store the reagent? This is not indicated in the sample sheet. Room temperature I assume? Thank you
1 answer-
Helpful?
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