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N115

Sigma-Aldrich

Naltrindole hydrochloride

≥97.5% (HPLC), solid, δ-opioid receptor antagonist

Synonym(s):

NTI hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C26H26N2O3 · HCl
CAS Number:
111469-81-9
Molecular Weight:
450.96
MDL number:
MFCD00069313
UNSPSC Code:
12352200
PubChem Substance ID:
24278062
NACRES:
NA.77

product name

Naltrindole hydrochloride, solid

form

solid

storage condition

desiccated

color

off-white

solubility

methanol: 4.5 mg/mL
H2O: 8 mg/mL

storage temp.

−20°C

SMILES string

Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7ccccc7c6C[C@@]35O)CC8CC8

InChI

1S/C26H26N2O3.ClH/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14;/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2;1H/t20-,24+,25+,26-;/m1./s1

InChI key

KNJKRQXCFJCQHC-IDRHMUJXSA-N

Gene Information

human ... OPRD1(4985)

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Biochem/physiol Actions

Highly selective, non-peptide δ-opioid receptor antagonist that crosses the blood-brain barrier.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J L Nano et al.
Pflugers Archiv : European journal of physiology, 439(5), 547-554 (2000-04-14)
Using 3H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (3H-DADLE) as a radioligand, delta-opioid binding sites on the IRD 98 rat epithelial cell line were identified. These sites were found to be reversible, saturable, specific and displayed high affinity for DADLE. Scatchard analysis revealed a dissociation constant
W Bilecki et al.
European journal of pharmacology, 390(1-2), 1-6 (2000-03-10)
A growing body of evidence supports an important role of the transcription factor cAMP responsive element binding protein (CREB) in mediating opioid-induced changes in the cAMP pathway. Regulation of CREB and subsequent changes in gene expression may underlie some long-term
Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist.
P S Portoghese et al.
European journal of pharmacology, 146(1), 185-186 (1988-01-27)

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