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C6352

CTAP

≥95%

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Pack SizeSKUAvailabilityPrice
1 mg
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CZK 5,630.00

About This Item

Empirical Formula (Hill Notation):
C51H69N13O11S2
CAS Number:
103429-32-9
Molecular Weight:
1104.30
NACRES:
NA.32
PubChem Substance ID:
329775120
UNSPSC Code:
12352200
MDL number:
MFCD00671434

CZK 5,630.00

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Quality Level

200

assay

≥95%

form

powder

UniProt accession no.

Q62923

storage temp.

−20°C

SMILES string

C[C@@H](O)[C@H](NC(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc5ccccc5)[C@@H](C)O)C(N)=O

InChI

1S/C51H69N13O11S2/c1-26(65)39(42(53)68)62-49(75)41-51(3,4)77-76-25-38(61-43(69)33(52)21-28-11-6-5-7-12-28)47(73)59-36(22-29-16-18-31(67)19-17-29)45(71)60-37(23-30-24-57-34-14-9-8-13-32(30)34)46(72)58-35(15-10-20-56-50(54)55)44(70)63-40(27(2)66)48(74)64-41/h5-9,11-14,16-19,24,26-27,33,35-41,57,65-67H,10,15,20-23,25,52H2,1-4H3,(H2,53,68)(H,58,72)(H,59,73)(H,60,71)(H,61,69)(H,62,75)(H,63,70)(H,64,74)(H4,54,55,56)/t26-,27-,33-,35+,36+,37-,38+,39+,40+,41-/m1/s1

InChI key

OFMQLVRLOGHAJI-FGHAYEPSSA-N

Gene Information

rat ... Pnoc(25516)

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This Item
P5296EMU087231EMU020531
CTAP ≥95%

Sigma-Aldrich

C6352

CTAP

CTOP ≥97% (HPLC)

Sigma-Aldrich

P5296

CTOP

MISSION® esiRNA targeting mouse Pno1

Sigma-Aldrich

EMU087231

MISSION® esiRNA

MISSION® esiRNA targeting mouse Slc20a2

Sigma-Aldrich

EMU020531

MISSION® esiRNA

assay

≥95%

assay

≥97% (HPLC)

assay

-

assay

-

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

form

powder

form

powder

form

lyophilized powder

form

lyophilized powder

UniProt accession no.

Q62923

UniProt accession no.

Q64387

UniProt accession no.

-

UniProt accession no.

-

Gene Information

rat ... Pnoc(25516)

Gene Information

mouse ... Pnoc(18155)

Gene Information

mouse ... PNO1(66249), Pno1(66249)

Gene Information

mouse ... SLC20A2(20516), Slc20a2(20516)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Application

CTAP has been used as a μ-opioid receptor (MOR) antagonist:
  • to study the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitor isoleucine-proline-isoleucine (IPI) and vildagliptin in carrageenan-induced inflammation
  • to study the role of MOR in glutamate and gamma-aminobutyric acid (GABA) efflux during predator stress in rats[1]
  • to determine the endogenous opioid peptide involved in blocking pain induced by activated gastrin-releasing peptide (Grp+) neurons

Biochem/physiol Actions

CTAP is a peptide antagonist produced from somatostatin analogs.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL7841
BCCF0591
BCCC0540
BCBV7821
BCBS0886V

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Leaky gate model: intensity-dependent coding of pain and itch in the spinal cord
Sun S, et al.
Neuron, 93(4), 840-853 (2017)
T J Abbruscato et al.
The Journal of pharmacology and experimental therapeutics, 280(1), 402-409 (1997-01-01)
D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) is a cyclic, penicillamine-containing octapeptide that is structurally similar to somatostatin and displays greater antagonist potency and selectivity for mu-opioid receptors, compared with the classical mu-selective antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2. The aim of this study was to determine whether CTAP
Chloe M Stanton et al.
Scientific reports, 7(1), 12147-12147 (2017-09-25)
Late-onset retinal degeneration (L-ORD) is a rare autosomal dominant retinal dystrophy, characterised by extensive sub-retinal pigment epithelium (RPE) deposits, RPE atrophy, choroidal neovascularisation and photoreceptor cell death associated with severe visual loss. L-ORD shows striking phenotypic similarities to age-related macular
Kevin Caref et al.
eLife, 7 (2018-03-28)
When relatively sated, people (and rodents) are still easily tempted to consume calorie-dense foods, particularly those containing fat and sugar. Consumption of such foods while calorically replete likely contributes to obesity. The nucleus accumbens (NAc) opioid system has long been
E J Bilsky et al.
The Journal of pharmacology and experimental therapeutics, 277(1), 484-490 (1996-04-01)
Previous studies measuring opioid inhibition of cyclic adenosine monophosphate in SH-SY5Y cells supported the hypothesis that continuous agonist stimulation causes a gradual conversion of the mu opioid receptor to a sensitized or constitutively active state termed mu*. Conversion to mu*
View All Related Papers

Global Trade Item Number

SKUGTIN
C6352-1MG04061826152607

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