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M6690

MDL 28170

≥90% (TLC), calpain I and II inhibitor

Synonym(s):

Calpain Inhibitor III

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Size/SKUAvailabilityPrice
25 mg
Please contact Customer Service for Availability
CZK 6,430.00

About This Item

Empirical Formula (Hill Notation):
C22H26N2O4
CAS Number:
88191-84-8
Molecular Weight:
382.45
UNSPSC Code:
12352200
PubChem Substance ID:
24278565
NACRES:
NA.77
MDL number:
MFCD00798796
Assay:
≥90% (TLC)

CZK 6,430.00

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Product Name

MDL 28170, ≥90% (TLC)

Quality Segment

200

assay

≥90% (TLC)

composition

Peptide Content, >90%

solubility

DMSO: 26 mg/mL, H2O: insoluble, methanol: soluble

shipped in

wet ice

storage temp.

2-8°C

SMILES string

[H]C(=O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C

InChI

1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1

InChI key

NGBKFLTYGSREKK-ANYOKISRSA-N

Gene Information

human ... CAPN1(823), CAPN2(824)

Application

MDL 28170 has been used as a calpain inhibitor:
  • to study its effects on neuroinflammation and necroptosis in rat model of cardiac arrest[1]
  • to analyze its effects on the degradation of neuronal nitric oxide synthase (nNOS) in beef semimembranosus muscle[2]
  • to study its protective effects against traumatic brain injury and survival of bone marrow-derived mesenchymal stem cells (BMSCs) in rat brain[3]

Biochem/physiol Actions

MDL 28170 exhibits neuroprotective effects against spinal cord injury, focal cerebral ischemia, and neonatal hypoxia-ischemia in rats.[4] It also shows anti-inflammatory and anti-neurodegenerative properties.[3] MDL 28170 crosses the blood-brain barrier and penetrates readily through the cell membranes.[1]
MDL 28170 is a potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Reduced occurrence of apoptosis in H2O2 and A23187 treated PC12 cells. γ-secretase-inhibitor.
Potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons.

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This Item
208722208743444264
MDL 28170 ≥90% (TLC)

Sigma-Aldrich

M6690

MDL 28170

Calpain Inhibitor III The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

208722

Calpain Inhibitor III

Calpain Inhibitor XI The Calpain Inhibitor XI, also referenced under CAS 145731-49-3, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

208743

Calpain Inhibitor XI

MMP Inhibitor III The MMP Inhibitor III, also referenced under CAS 927827-98-3, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

444264

MMP Inhibitor III

assay

≥90% (TLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (TLC)

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 26 mg/mL, methanol: soluble, H2O: insoluble

solubility

DMSO: 20 mg/mL (Use only anhydrous DMSO.)

solubility

DMSO: 5 mg/mL

solubility

DMSO: 5 mg/mL

Gene Information

human ... CAPN1(823), CAPN2(824)

Gene Information

-

Gene Information

-

Gene Information

-

composition

Peptide Content, >90%

composition

-

composition

-

composition

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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