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L5793

Leupeptin

powder, ≥95% (HPLC)

Synonym(s):

Leupeptin hemisulfate salt, Acetyl-Leu-Leu-Arg-al, N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt

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Pack SizeSKUAvailabilityPrice
5 mg

Available to ship TODAYfromSchnelldorf Distribution

CZK 6,900.00
25 mg

Available to ship TODAYfromSchnelldorf Distribution

CZK 22,300.00
100 mg

Estimated to ship onJune 15, 2026fromSchnelldorf Distribution

CZK 57,900.00

About This Item

Linear Formula:
C20H38N6O4 · 1/2H2SO4
CAS Number:
103476-89-7
Molecular Weight:
475.59
UNSPSC Code:
12352202
PubChem Substance ID:
24896420
NACRES:
NA.77
MDL number:
MFCD00037012

CZK 6,900.00

Available to ship TODAYDetails

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Product Name

Leupeptin, BioUltra, microbial, ≥95% (HPLC)

biological source

microbial

Quality Segment

200

product line

BioUltra

assay

≥95% (HPLC)

form

powder

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

OS(O)(=O)=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O

InChI

1S/2C20H38N6O4.H2O4S/c2*1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;1-5(2,3)4/h2*11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H2,1,2,3,4)/t2*15-,16-,17-;/m00./s1

InChI key

CIPMKIHUGVGQTG-VFFZMTJFSA-N

Biochem/physiol Actions

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Analysis Note

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

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This Item
L2884L851162070
Leupeptin BioUltra, microbial, ≥95% (HPLC)

Sigma-Aldrich

L5793

Leupeptin

Leupeptin microbial, ≥90% (HPLC)

Sigma-Aldrich

L2884

Leupeptin

Leupeptin synthetic, ≥85% (HPLC)

Sigma-Aldrich

L8511

Leupeptin

Leupeptin >4000 U/mg

Sigma-Aldrich

62070

Leupeptin

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥85% (HPLC)

assay

-

biological source

microbial

biological source

microbial

biological source

synthetic

biological source

synthetic

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

100

form

powder

form

powder

form

powder

form

powder

solubility

H2O: 50 mg/mL

solubility

H2O: 10 mM (Solutions are stable for a week at 4 °C. Stock solutions are stable up to 6 months at −20 °C.), H2O: 50 mg/mL

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000520726
0000492562
0000520726
0000492563
0000492563

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Global Trade Item Number

SKUGTIN
L5793-25MG04061833219386
L5793-100MG04061833219379
L5793-5MG04061833958469

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