L133
L-750,667 trihydrochloride
solid
Synonym(s):
3-[4-(4-Iodophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C18H19IN4 · 3HCl
CAS Number:
Molecular Weight:
527.66
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
Form:
solid
form
solid
color
white
solubility
DMSO: 10 mg/mL
SMILES string
Cl.Cl.Cl.Ic1ccc(cc1)N2CCN(CC2)Cc3c[nH]c4ncccc34
InChI
1S/C18H19IN4.3ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;;;/h1-7,12H,8-11,13H2,(H,20,21);3*1H
InChI key
YOURSPNOEWYAKO-UHFFFAOYSA-N
Gene Information
human ... DRD4(1815)
Application
Useful in characterizing the extracellular domain of the D4 dopamine receptor.[1]
Biochem/physiol Actions
Selective D4 dopamine receptor antagonist.
Disclaimer
Hygroscopic
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Margareta K Sorenson et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(45), 16722-16727 (2006-11-01)
The dissociable sigma subunit of bacterial RNA polymerase is required for the promoter-specific initiation of transcription. When bound to RNA polymerase, sigma makes sequence-specific promoter contacts and plays a crucial role in DNA melting. In isolation, however, sigma lacks significant
J A Schetz et al.
Molecular pharmacology, 57(1), 144-152 (2000-01-05)
The molecular determinants that govern selective ligand binding to the rat D(4) dopamine receptor were investigated by substituting D(2) dopamine receptor sequences into a D(4) dopamine receptor background. The resulting mutant D(4) dopamine receptors were then screened with a panel
S Patel et al.
Molecular pharmacology, 50(6), 1658-1664 (1996-12-01)
We identified a novel azaindole derivative, L-750,667, that has high affinity (Ki = 0.51 nM) and >2000-fold selectivity for D4 dopamine receptors compared with its activity at D2 and D3 dopamine receptors. L-750,667 had little affinity for rat D1/D5 dopamine
Global Trade Item Number
| SKU | GTIN |
|---|---|
| L133-25MG | 04061832948027 |
| L133-5MG | 04061832948034 |