K2644
Kisspeptin-234 trifluoroacetate salt
≥95% (HPLC)
Synonym(s):
kisspeptin-10 peptide 234
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 mg | Please contact Customer Service for Availability | CZK 4,460.00 |
About This Item
Empirical Formula (Hill Notation):
C63H78N18O13 · xC2HF3O2
CAS Number:
Molecular Weight:
1295.41 (free base basis)
NACRES:
NA.32
UNSPSC Code:
12352200
Quality Segment
assay
≥95% (HPLC)
form
film
color
colorless to white
solubility
H2O: >1 mg/mL
storage temp.
−20°C
Biochem/physiol Actions
Kisspeptin-234 is a 10-amino acid peptide antagonist with potent neutral antagonist activity at GPR-54 and competes directly at the Kisspeptin-10 binding site.
Kisspeptin-234 is a 10-amino acid peptide antagonist with potent neutral antagonist activity at GPR-54 and competes directly at the Kisspeptin-10 binding site. Kisspeptin-234 is the first reported antagonist for the kisspeptin-1/GPR-54 signaling system.
Gonadotropin-releasing hormone (GnRH) modulates the hypothalamic-pituitary-gonadal axis, enabling the brain to control reproductive processes. Kisspeptin-1 is a peptide neurotransmitter released from afferent neurons onto GnRH neurons, where it binds to and activates to the orphan receptor GPR-54 to regulate release of GnRH. Regulation of kisspeptin/GPR-54 signaling presents an opportunity for reproductive therapeutics above the level of GnRH and gonadotropin secretion. Pharmacological and selective tools are needed to better understand kisspeptin-1/GPR-54 signaling. Analogs of kisspeptin-10, a 10-amino acid portion of kisspeptin-1, were designed to be full and neutral antagonists of GPR-54.
Gonadotropin-releasing hormone (GnRH) modulates the hypothalamic-pituitary-gonadal axis, enabling the brain to control reproductive processes. Kisspeptin-1 is a peptide neurotransmitter released from afferent neurons onto GnRH neurons, where it binds to and activates to the orphan receptor GPR-54 to regulate release of GnRH. Regulation of kisspeptin/GPR-54 signaling presents an opportunity for reproductive therapeutics above the level of GnRH and gonadotropin secretion. Pharmacological and selective tools are needed to better understand kisspeptin-1/GPR-54 signaling. Analogs of kisspeptin-10, a 10-amino acid portion of kisspeptin-1, were designed to be full and neutral antagonists of GPR-54.
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This Item | |||
|---|---|---|---|
| assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level - |
| form film | form film | form powder | form film |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility H2O: >1 mg/mL | solubility H2O: 0.5 mg/mL, clear | solubility H2O: >2 mg/mL | solubility - |
| color colorless to white | color colorless to white | color white to off-white | color white to beige |
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| K2644-1MG | 04061833868355 |