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J4145

Jervine

≥98% (HPLC), powder

Synonym(s):

(3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine

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Size/SKUAvailabilityPrice
1 mg
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CZK 4,180.00
CZK 3,553.00

About This Item

Empirical Formula (Hill Notation):
C27H39NO3
CAS Number:
469-59-0
Molecular Weight:
425.60
NACRES:
NA.77
PubChem Substance ID:
24896194
UNSPSC Code:
51111800
EC Number:
207-417-9
MDL number:
MFCD01684066
Assay:
≥98% (HPLC)
Form:
powder

CZK 3,553.00

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Quality Segment

100

assay

≥98% (HPLC)

form

powder

solubility

methanol: >2 mg/mL, H2O: insoluble

storage temp.

−20°C

SMILES string

[H][C@@]12C[C@H](C)CN[C@@]1([H])[C@@H](C)[C@@]3(CC[C@]4([H])C(=C3C)C(=O)[C@@]5([H])[C@@]4([H])CC=C6C[C@@H](O)CC[C@]56C)O2

InChI

1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1

InChI key

CLEXYFLHGFJONT-DNMILWOZSA-N

Gene Information

human ... EBP(10682)

General description

Jervine is a steroid alkaloid present in Veratrum californicum.[1][2]

Biochem/physiol Actions

Jervine is a potent teratogenic agent.[3] It can induce apoptosis in leukemia cells[1] and MUTZ-1 cells. Jervine is an inhibitor of Hedgehog signaling. It exhibits anti-cancer effects on human prostate cancer. It also increases the chemosensitivity of breast cancer cells to doxorubicin treatment.[2] Jervine may be used for treating hypertension and heart disease.[3]
Jervine is a sonic hedgehog (Shh) pathway inhibitor.

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This Item
C4116PHL83515SML0147
Jervine ≥98% (HPLC), powder

Sigma-Aldrich

J4145

Jervine

Cyclopamine hydrate ≥98% (HPLC)

Sigma-Aldrich

C4116

Cyclopamine hydrate

Jervine phyproof® Reference Substance

PHL83515

Jervine

Drospirenone ≥98% (HPLC)

Sigma-Aldrich

SML0147

Drospirenone

form

powder

form

solid

form

-

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95.0% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

methanol: >2 mg/mL, H2O: insoluble

solubility

DMSO: soluble ≥5 mg/mL, H2O: insoluble

solubility

-

solubility

DMSO: ≥15

Gene Information

human ... EBP(10682)

Gene Information

human ... EBP(10682)

Gene Information

-

Gene Information

human ... NR3C2(4306), PGR(5241)

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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