I3282

Monoclonal Anti-Interleukin-10 Receptor α antibody produced in mouse

clone 37607, purified immunoglobulin, lyophilized powder

• Synonym(s): Anti-IL-10 Receptor α
• UNSPSC Code: 51111800
• NACRES: NA.41
• MDL number: MFCD03792423
• Conjugate: unconjugated
• Clone: 37607, monoclonal
• Application: Neutral
• Citations: 5

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 37607, monoclonal
• form: lyophilized powder
• species reactivity: human
• technique(s): neutralization: suitable
• isotype: IgG1
• UniProt accession no.: Q13651
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... IL10RA(3587)

Description

General description

Interleukin-10 (IL-10) is a pleotropic cytokine with anti-inflammatory and immunosuppressive functions. It is the key cytokine that regulates the host inflammatory responses to bacterial, fungal and viral pathogens. IL-10 is secreted by a variety of cells including T cells, B cells, dendritic cells, eosinophils, natural killer cells and mast cells. The effects of IL-10 are mediated by binding to the IL-10R, consisting of α and β subunits. The signalling through IL-10R activates Jak1, Tyk2 protein kinases and JAK/STAT3 pathways. IL-10R is involved in suppression of innate immunity to kill pathogens and inhibits the release of reactive oxygen and nitrogen species from activated macrophages. Regulation of IL-10R mediated signalling is important in infections, inflammatory responses in autoimmune encephalomyelitis, endotoxic shock and chronic enterocolitis
Monoclonal Anti-Interleukin-10 Receptor α (IL-10 Rα) recognizes human IL-10 Rα. The antibody does not cross-react with recombinant mouse IL-10 Ra.

Immunogen

purified recombinant human IL-10 soluble receptor α expressed in insect Sf 21 cells.

Application

Anti-interleukin-10 receptor α antibody is suitable for neutralization reactions (ND50 is 0.03-0.1 μg/ml).

Biochem/physiol Actions

The antibody has the ability to block cell surface human IL-10 Rα mediated bioactivity induced by recombinant human IL-10. The antibody does not cross-react with mouse IL-10 Rα.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)