H9415

5HPP-33

≥98% (HPLC), solid

• Synonym(s): 2-[2,6-bis(1-Methylethyl)phenyl]-5-hydroxy-1H-isoindole-1,3(2H)-dione, 5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione
• Empirical Formula (Hill Notation): C₂₀H₂₁NO₃
• CAS Number: 105624-86-0
• Molecular Weight: 323.39
• NACRES: NA.77
• PubChem Substance ID: 329815265
• UNSPSC Code: 12352200
• MDL number: MFCD03085294
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• solubility: DMSO: >20 mg/mL
• storage temp.: 2-8°C
• SMILES string: CC(C)c1cccc(C(C)C)c1N2C(=O)c3ccc(O)cc3C2=O
• InChI: 1S/C20H21NO3/c1-11(2)14-6-5-7-15(12(3)4)18(14)21-19(23)16-9-8-13(22)10-17(16)20(21)24/h5-12,22H,1-4H3
• InChI key: LAKWINYVWJPHQW-UHFFFAOYSA-N

Description

Biochem/physiol Actions

5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules.

5HPP-33 is a thalidomide derivative which was reported to be active as anticancer agent through stabilization of the microtubules. 5HPP-33 has shown inhibition of cell proliferation of both estrogen-dependent (MCF-7) and estrogen-independent (MDA-MB-231) breast cancer cells as well as other cell lines. A study in tubulin forming assay reported that 5HPP-33 acts as a microtubule formation inhibitor (IC50=810 nM).

Safety Information

• pictograms: GHS09
• signalword: Warning
• hcodes: H410
• pcodes: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves